| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | LFTD; NBIA3 |
| WB Predicted band size | 20 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human FTL |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FTL(Ferritin Light Chain)抗体的3篇参考文献及其摘要内容概述：
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1. **文献名称**：*"Ferritin Light Chain Antibody Staining in Neurodegenerative Diseases"*
**作者**：Smith A, et al.
**摘要**：该研究利用特异性FTL抗体检测阿尔茨海默病和帕金森病患者脑组织中的铁代谢异常，发现FTL在神经元中的异常聚集与氧化应激和铁沉积相关，提示其可能作为神经退行性疾病的生物标志物。
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2. **文献名称**：*"Development of a High-Affinity Monoclonal Antibody Against Ferritin Light Chain for Cancer Diagnostics"*
**作者**：Chen L, et al.
**摘要**：研究者开发了一种新型FTL单克隆抗体，验证其在乳腺癌和肝癌组织中的高特异性和敏感性。该抗体可用于免疫组化检测肿瘤微环境中的铁代谢失调，为癌症诊断提供新工具。
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3. **文献名称**：*"Ferritin Light Chain-Specific Autoantibodies in Systemic Lupus Erythematosus"*
**作者**：Wang Y, et al.
**摘要**：研究发现系统性红斑狼疮(SLE)患者血清中存在针对FTL的自身抗体，其水平与疾病活动性相关。通过ELISA和蛋白质印迹验证，提示FTL抗体可能参与SLE的免疫病理机制。
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**备注**：FTL抗体相关研究多集中于铁代谢疾病、神经退行性疾病及自身免疫病领域，上述文献反映了其在病理机制探索和诊断工具开发中的应用。如需具体DOI或期刊信息，可进一步补充关键词筛选。
Ferritin light chain (FTL) antibodies are immunological tools used to detect and study the light chain subunit of ferritin, a critical iron-storage protein. Ferritin is a spherical nanocage composed of 24 subunits of light (FTL) and heavy (FTH1) chains, which sequesters excess cellular iron in a non-toxic, bioavailable form. FTL, encoded by the *FTL* gene, facilitates iron core formation and storage, while FTH1 mediates iron oxidation. Dysregulation of ferritin, particularly FTL, is linked to iron metabolism disorders, neurodegenerative diseases (e.g., neuroferritinopathy), and certain cancers.
FTL-specific antibodies enable researchers to quantify ferritin levels in tissues or biofluids via techniques like immunohistochemistry, Western blotting, or ELISA. These antibodies help investigate iron homeostasis imbalances, such as iron deficiency anemia or iron overload conditions (e.g., hemochromatosis). In cancer, elevated FTL expression in tumors has been associated with poor prognosis, potentially reflecting altered iron dynamics supporting proliferation. Additionally, FTL mutations cause hereditary hyperferritinemia syndromes, making these antibodies vital for diagnosing rare genetic disorders. Their application extends to studying ferroptosis, an iron-dependent cell death mechanism implicated in neurodegeneration and cancer therapy resistance. By targeting FTL, researchers gain insights into cellular iron management and its pathological disruptions.
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