| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | HA1, Ha-1, hHa1, KRTHA1 |
| WB Predicted band size | 47 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human KRT31 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于KRT31抗体的3篇模拟参考文献示例(基于学术研究常见方向，非真实文献)：
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1. **文献名称**：*Characterization of a Novel Monoclonal Antibody Against Human Keratin 31 for Hair Follicle Differentiation Studies*
**作者**：Smith A, et al.
**摘要**：本研究开发了一种高特异性单克隆抗体(克隆号K31-2B5)，用于检测人毛囊内根鞘中的KRT31蛋白。通过免疫组化和Western blot验证了抗体在正常毛囊组织中的特异性，并发现其在斑秃患者样本中表达显著下调，提示KRT31可能与毛囊分化障碍相关。
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2. **文献名称**：*KRT31 as a Biomarker in Scarring Alopecia: Immunohistochemical Analysis Using a Polyclonal Antibody Approach*
**作者**：Chen L, et al.
**摘要**：作者利用兔源多克隆抗体(货号ab-K31-P)对瘢痕性脱发患者头皮样本进行染色，发现KRT31在受损毛囊周围的异常表达模式与纤维化进程相关。研究强调了KRT31抗体在诊断瘢痕性毛发疾病中的潜在临床应用价值。
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3. **文献名称**：*Comparative Proteomic Profiling of Hair Shaft Keratins Using KRT31-Specific Antibodies*
**作者**：Wang Y, et al.
**摘要**：通过KRT31抗体(商业来源：Sigma-Aldrich, K31-7C12)结合质谱分析，揭示了KRT31与KRT85等角蛋白在毛干中的相互作用网络，为遗传性毛发结构异常疾病的分子机制提供了新见解。
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**注意**：以上文献为模拟内容，实际引用时请查询PubMed、Web of Science等数据库获取真实发表的研究。若需具体文献协助，建议补充关键词(如物种、应用场景)以便进一步筛选。
The KRT31 antibody targets keratin 31. a protein encoded by the *KRT31* gene, which belongs to the type I keratin family. Keratins are intermediate filament proteins critical for maintaining structural integrity in epithelial cells, particularly in hair follicles, nails, and skin. KRT31 is an acidic keratin (type I) that pairs with basic keratins (type II) like KRT85 to form heterodimers, essential for hair shaft strength and resilience. Mutations in *KRT31* are linked to hereditary hair disorders such as monilethrix, characterized by brittle, beaded hair and follicular hyperkeratosis.
KRT31 antibodies are widely used in research to study hair biology, epithelial differentiation, and keratin-related pathologies. They enable detection of KRT31 expression in tissues via techniques like immunohistochemistry, Western blotting, and immunofluorescence. These tools help elucidate the protein's role in hair follicle cycling, wound healing, and diseases like ectodermal dysplasias. Commercially available KRT31 antibodies are typically raised in rabbits or mice, validated for specificity against human or model organism samples. Recent studies also explore KRT31's potential as a biomarker in certain cancers, given keratin dysregulation in epithelial malignancies. However, cross-reactivity with related keratins remains a technical consideration, necessitating careful experimental controls.
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