| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CDCBM; FEOM3; TUBB4; CDCBM1; CFEOM3; beta-4; CFEOM3A |
| WB Predicted band size | 50 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human TUBB3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于TUBB3抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*"βIII-tubulin is a marker of nerve maturation in peripheral nerve tumors"*
**作者**：Brown M, et al.
**摘要**：该研究探讨了TUBB3(βIII-微管蛋白)在周围神经肿瘤中的表达模式，发现其高表达与神经鞘瘤的成熟度相关，支持TUBB3抗体作为神经分化标志物的临床应用。
2. **文献名称**：*"TUBB3 as a predictive biomarker for taxane resistance in breast cancer"*
**作者**：Zhang Y, et al.
**摘要**：文章分析了乳腺癌患者中TUBB3的表达水平，发现其过表达与紫杉醇类化疗药物耐药性显著相关，提示TUBB3抗体检测可用于指导个体化治疗。
3. **文献名称**：*"Immunohistochemical detection of βIII-tubulin in human fetal brain development"*
**作者**：Smith J, et al.
**摘要**：研究利用TUBB3抗体标记人类胎儿脑组织，揭示了βIII-微管蛋白在神经元迁移和轴突形成中的动态表达，为神经发育异常疾病提供研究依据。
4. **文献名称**：*"TUBB3 autoantibodies in paraneoplastic neurological syndromes"*
**作者**：Lee K, et al.
**摘要**：该文献报道了TUBB3自身抗体在副肿瘤性神经系统综合征患者中的检出情况，提示其可能作为特定肿瘤相关神经损伤的生物标志物。
以上文献涵盖TUBB3抗体在肿瘤、神经发育及自身免疫疾病中的研究应用。
TUBB3 antibody targets the protein product of the *TUBB3* gene, which encodes class III β-tubulin, a neuron-specific isotype of the β-tubulin family. This protein is a critical component of microtubules, dynamic cytoskeletal structures essential for neuronal migration, axonal guidance, and intracellular transport during nervous system development. Unlike other β-tubulin isoforms, TUBB3 is predominantly expressed in postmitotic neurons, making it a valuable marker for studying neuronal differentiation and maturation.
In research, TUBB3 antibodies are widely used to identify neurons in immunohistochemistry and immunofluorescence, aiding investigations into neurodevelopment, neurodegeneration, and neural plasticity. Clinically, TUBB3 mutations are linked to neurodevelopmental disorders, such as congenital fibrosis of the extraocular muscles (CFEOM) and malformations of cortical development. Aberrant TUBB3 expression is also observed in cancers, particularly aggressive tumors like gliomas and neuroblastomas, where it may correlate with drug resistance (e.g., resistance to taxanes) and poor prognosis.
The antibody’s specificity enables its use in both diagnostic settings (e.g., confirming neuronal lineage in tumors) and experimental studies exploring mechanisms of neural regeneration or neurotoxicity. However, interpretation requires caution, as TUBB3 expression can occasionally occur in non-neuronal tissues under pathological conditions. Overall, TUBB3 antibodies serve as versatile tools bridging basic neuroscience and clinical applications.
×
