| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | GT; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2 |
| Entrez GeneID | 3674 |
| clone | 2E10C9 |
| WB Predicted band size | 113.4kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human ITGA2B (AA: 45-149) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于 **ITGA2B抗体** 的3篇代表性文献示例(注：内容为模拟，非真实文献)：
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1. **标题**: *ITGA2B基因突变在Glanzmann血栓无力症中的功能研究*
**作者**: Smith J, et al.
**摘要**: 本研究通过分析Glanzmann血栓无力症患者的ITGA2B基因突变，发现其编码的αIIbβ3整合素复合物表达异常，导致血小板聚集功能缺陷。采用ITGA2B特异性抗体进行流式细胞术检测，证实了突变对血小板表面受体分布的影响。
2. **标题**: *抗ITGA2B单克隆抗体抑制肿瘤转移的机制探索*
**作者**: Chen L, et al.
**摘要**: 研究发现，某些肿瘤细胞通过异常表达ITGA2B促进转移。实验显示，靶向ITGA2B的单克隆抗体可阻断肿瘤细胞与纤维蛋白原的相互作用，显著抑制小鼠模型中的肺转移，提示其潜在治疗价值。
3. **标题**: *ITGA2B抗体在血小板功能自动化检测中的临床应用*
**作者**: Wang H, et al.
**摘要**: 开发了一种基于ITGA2B抗体的自动化流式检测方法，用于快速诊断血小板相关疾病。该抗体特异性识别αIIbβ3复合物，与传统方法相比，提高了血小板无力症和活化异常疾病的检测灵敏度和效率。
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**说明**：上述文献方向覆盖了ITGA2B抗体的 **疾病机制**、**治疗应用** 和 **诊断技术**。如需真实文献，建议通过PubMed或Google Scholar搜索关键词“ITGA2B antibody”“Glanzmann thrombasthenia”“αIIbβ3 integrin”。
The ITGA2B antibody targets integrin alpha-IIb (αIIb), a critical subunit of the αIIbβ3 integrin heterodimer (glycoprotein IIb/IIIa). This integrin is predominantly expressed on platelets and megakaryocytes, playing a pivotal role in platelet aggregation and thrombus formation. The αIIbβ3 complex binds fibrinogen, von Willebrand factor, and other ligands upon platelet activation, mediating crosslinking during hemostasis.
Mutations in the ITGA2B gene are linked to Glanzmann thrombasthenia, a rare bleeding disorder characterized by defective platelet aggregation. ITGA2B antibodies are essential tools in diagnosing this condition, often via flow cytometry or immunoassays to assess αIIbβ3 expression or function.
In research, ITGA2B antibodies are used to study platelet activation mechanisms, thrombosis, and inflammation. They also aid in developing antiplatelet therapies; for example, drugs like abciximab block αIIbβ3 to prevent clotting in cardiovascular diseases. Additionally, these antibodies help investigate integrin signaling pathways and their roles in cancer metastasis or immune responses.
Overall, ITGA2B antibodies serve both clinical and experimental purposes, bridging insights into platelet biology, genetic disorders, and therapeutic interventions.
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