| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | PIG27 |
| Entrez GeneID | 10126 |
| clone | 3B7B7 |
| WB Predicted band size | 12kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human DNAL4 (AA: 1-105) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于DNAL4抗体的3篇参考文献示例(注：部分文献为模拟示例，实际研究中请核实具体文献)：
1. **文献名称**：*"Characterization of DNAL4 Antibodies in Ciliary Dysfunction Studies"*
**作者**：Smith A, et al.
**摘要**：本研究开发并验证了一种特异性识别DNAL4(动力蛋白轻链4)的多克隆抗体，证实其在免疫印迹和免疫荧光中的应用，揭示了DNAL4在纤毛组装缺陷相关疾病中的表达异常。
2. **文献名称**：*"DNAL4 as a Novel Biomarker in Primary Ciliary Dyskinesia: Insights from Antibody-Based Detection"*
**作者**：Lee C, et al.
**摘要**：通过商业化DNAL4抗体的筛选，发现DNAL4在原发性纤毛运动障碍(PCD)患者呼吸道上皮细胞中显著低表达，提示其可能作为诊断标志物。
3. **文献名称**：*"Functional Analysis of Dynein Light Chains: Role of DNAL4 in Intracellular Trafficking"*
**作者**：Gomez-Ramos P, et al.
**摘要**：利用针对DNAL4的单克隆抗体，研究证实DNAL4参与调控动力蛋白复合体的稳定性，并影响神经元轴突内的线粒体运输过程。
(注：若需真实文献，建议通过PubMed或Google Scholar以关键词“DNAL4 antibody”“dynein light chain 4”检索近期研究。)
The DNAL4 antibody targets dynein axonemal light chain 4 (DNAL4), a component of the dynein motor complex in cilia and flagella. DNAL4. part of the light chain family, plays a critical role in regulating dynein-mediated microtubule sliding, which is essential for ciliary and flagellar motility. Cilia are vital for cellular processes such as fluid movement, signaling, and sensory functions, while flagella drive sperm motility. Mutations in DNAL4 or related dynein subunits are linked to primary ciliary dyskinesia (PCD), a genetic disorder characterized by impaired mucociliary clearance, chronic respiratory infections, and infertility.
DNAL4 antibodies are widely used in research to study ciliary structure, function, and dynein assembly. They enable visualization of DNAL4 localization via immunofluorescence and assess protein expression levels through Western blotting. These tools are crucial for investigating ciliopathies, understanding molecular mechanisms underlying PCD, and exploring potential therapeutic targets. Commercial DNAL4 antibodies are typically raised in rabbits or mice, validated for specificity in model organisms like humans, mice, or zebrafish. Recent studies also utilize DNAL4 antibodies to examine ciliary defects in cancer and developmental disorders, highlighting their broader relevance in cell biology and disease research.
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