| WB | 1/500 - 1/2000 | Human,Mouse,Rat,Rabbit |
| IF | 咨询技术 | Human,Mouse,Rat,Rabbit |
| IHC | 1/100 - 1/500 | Human,Mouse,Rat,Rabbit |
| ICC | 1/50 - 1/500 | Human,Mouse,Rat,Rabbit |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat,Rabbit |
| Elisa | 1/10000 | Human,Mouse,Rat,Rabbit |
| Aliases | ALDM; ALDHI; ALDH-E2 |
| Entrez GeneID | 217 |
| clone | 4G6A3 |
| WB Predicted band size | 56.3kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat,Monkey,Rabbit |
| Immunogen | Purified recombinant fragment of human ALDH2 (AA: 317-517) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于ALDH2抗体的3篇参考文献示例(内容基于假设性研究，供参考)：
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1. **文献名称**：*Development of a Monoclonal Antibody Against Human ALDH2 for Detecting Protein Expression in Alcohol-Related Liver Disease*
**作者**：Chen L, et al.
**摘要**：本研究开发了一种高特异性ALDH2单克隆抗体，通过免疫组化和Western blot验证其在酒精性肝病模型中的表达变化，发现ALDH2表达降低与肝损伤程度呈负相关。
2. **文献名称**：*ALDH2 rs671 Polymorphism and Myocardial Infarction: Role of ALDH2 Antibody in Clinical Diagnosis*
**作者**：Tanaka K, et al.
**摘要**：利用ALDH2抗体检测携带rs671突变患者的组织样本，发现ALDH2活性下降与心肌梗死风险增加相关，提示该抗体可用于心血管疾病的分子分型。
3. **文献名称**：*Immunohistochemical Analysis of ALDH2 in Esophageal Squamous Cell Carcinoma Using a Novel Polyclonal Antibody*
**作者**：Wang Y, et al.
**摘要**：报道了一种新型ALDH2多克隆抗体的开发，并在食管癌组织中验证其特异性，发现ALDH2高表达与患者生存率改善相关，为癌症预后评估提供工具。
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**注**：以上文献为示例性质，实际引用时建议通过PubMed或Google Scholar检索最新文献，并核对作者及摘要准确性。若需具体文献协助，可提供更详细的研究方向进一步筛选。
**Background of ALDH2 Antibodies**
Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme critical for metabolizing toxic aldehydes, including acetaldehyde (a byproduct of alcohol metabolism) and reactive lipid peroxidation products. The *ALDH2* gene exhibits a common polymorphism (Glu504Lys, rs671) prevalent in East Asian populations, which significantly reduces enzyme activity. This variant is linked to alcohol flushing syndrome, increased cancer risk, and susceptibility to cardiovascular and neurodegenerative diseases.
ALDH2 antibodies are immunological tools designed to detect and quantify ALDH2 protein expression, localization, or functional alterations in research. These antibodies, often polyclonal or monoclonal, are validated for techniques like Western blotting, immunohistochemistry, and ELISA. They help investigate ALDH2's role in cellular detoxification, oxidative stress response, and disease mechanisms. For instance, studies use ALDH2 antibodies to explore its protective effects in ischemic heart injury, its association with cancer stem cells, or its dysfunction in Alzheimer’s disease.
Given ALDH2's clinical relevance, these antibodies are vital for translational research, enabling insights into genetic susceptibility, biomarker discovery, and therapeutic targeting. Specificity validation across species (human, mouse, rat) and applications in diverse sample types (tissues, cell lines) ensure their utility in both basic and clinical studies.
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