Mouse Monoclonal SLC27A5 Antibody

The solute carrier family 27 member 5 (SLC27A5), also known as fatty acid transport protein 5 (FATP5), is a transmembrane protein primarily expressed in the liver. It plays a critical role in bile acid synthesis and long-chain fatty acid transport, contributing to lipid metabolism and energy homeostasis. SLC27A5 facilitates the uptake of bile acid precursors into hepatocytes and regulates the conversion of cholesterol into bile acids, making it essential for maintaining cholesterol balance and digestive functions. Antibodies targeting SLC27A5 are widely used in research to investigate its expression patterns, subcellular localization, and regulatory mechanisms in hepatic tissues. These antibodies are typically validated for applications such as Western blotting, immunohistochemistry, and immunofluorescence, often using liver-specific models or cell lines. Studies involving SLC27A5 antibodies have shed light on its involvement in metabolic disorders, including non-alcoholic fatty liver disease (NAFLD), cholestasis, and obesity. Additionally, research explores its interactions with nuclear receptors like FXR and LXR, which modulate lipid and glucose metabolism pathways. Reliable SLC27A5 antibodies are crucial for elucidating its pathophysiological roles and potential therapeutic targeting in liver-related diseases.