| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | 7B4; CD144 |
| Entrez GeneID | 1003 |
| clone | 3D5C7 |
| WB Predicted band size | 87.5kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | Purified recombinant fragment of human CDH5 (AA: 29-223 ) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇与CDH5(VE-cadherin)抗体相关的文献概览，基于典型研究场景整理：
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1. **文献名称**：*VE-cadherin antibodies modulate endothelial junctional plasticity and permeability*
**作者**：Gavard, J. et al.
**摘要**：本研究通过使用CDH5特异性抗体阻断VE-cadherin功能，揭示了其在调控内皮细胞间连接可塑性和血管通透性中的作用，发现抗体干预可促进炎症反应中白细胞的跨内皮迁移。
2. **文献名称**：*Targeting VE-cadherin in tumor vasculature: A monoclonal antibody approach*
**作者**：Liao, F. et al.
**摘要**：开发了一种靶向VE-cadherin的单克隆抗体，证明其能抑制肿瘤血管生成并增强化疗药物递送，通过免疫组化和体内成像验证了抗体在肿瘤内皮中的特异性结合。
3. **文献名称**：*VE-cadherin cleavage regulates endothelial barrier function in sepsis*
**作者**：Sullivan, D.P. & Muller, W.A.
**摘要**：利用抗CDH5抗体进行Western blot和免疫荧光实验，发现脓毒症中VE-cadherin的蛋白水解导致内皮屏障破坏，抗体检测为评估屏障完整性提供了关键工具。
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注：以上文献信息为示例性质，实际引用时请核对真实文献来源及细节。建议通过PubMed或Web of Science以“VE-cadherin antibody”或“CDH5 antibody”为关键词检索最新研究。
CDH5. also known as VE-cadherin (vascular endothelial cadherin), is a calcium-dependent transmembrane protein predominantly expressed in endothelial cells. It plays a critical role in maintaining vascular integrity and regulating endothelial cell-cell adhesion through the formation of adherens junctions. CDH5 is essential for angiogenesis, vascular development, and controlling vascular permeability. Dysregulation of CDH5 has been implicated in pathological conditions such as tumor metastasis, inflammation, and cardiovascular diseases.
CDH5 antibodies are immunological tools designed to detect and quantify the expression of this protein in research and diagnostic applications. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry to study endothelial cell behavior, vascular remodeling, and barrier function. Specific CDH5 antibodies can distinguish between phosphorylated or cleaved forms, aiding in the analysis of signaling pathways involved in vascular homeostasis. In cancer research, CDH5 antibodies help investigate tumor angiogenesis and metastatic mechanisms, as reduced CDH5 expression often correlates with increased vascular leakage and cancer cell dissemination. Additionally, they serve as biomarkers in studies exploring endothelial dysfunction in sepsis, atherosclerosis, or COVID-19-related vascular injury. Validated CDH5 antibodies are crucial for ensuring reproducibility in vascular biology research and therapeutic development targeting endothelial pathways.
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