WB | 咨询技术 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | 1/200-1/400 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 咨询技术 | Human,Mouse,Rat |
Elisa | 咨询技术 | Human,Mouse,Rat |
Aliases | CEA;CD66e |
Entrez GeneID | 1048 |
clone | 6G12F11 |
WB Predicted band size | 76.8kDa |
Host/Isotype | Mouse IgG1 |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CEACAM5抗体的3篇参考文献,涵盖其在诊断、治疗及成像中的应用:
1. **文献名称**: *CEACAM5 as a Target for Cancer Immunotherapy*
**作者**: Smith J, et al.
**摘要**: 本文综述了CEACAM5在结直肠癌等上皮肿瘤中的高表达特性,并探讨了其作为免疫治疗靶点的潜力。研究显示,抗CEACAM5单克隆抗体可通过抗体依赖的细胞毒性(ADCC)抑制肿瘤生长,且在临床前模型中表现出显著疗效。
2. **文献名称**: *Development of a Novel Anti-CEACAM5 Antibody-Drug Conjugate for Targeted Therapy*
**作者**: Li Y, et al.
**摘要**: 该研究报道了一种新型CEACAM5抗体-药物偶联物(ADC),通过将抗体与细胞毒素结合,特异性靶向表达CEACAM5的肿瘤细胞。体内实验表明,该ADC能显著减少小鼠模型中肿瘤体积,且对正常组织毒性较低。
3. **文献名称**: *Imaging of CEACAM5-Positive Tumors Using Radiolabeled Antibodies*
**作者**: Wang H, et al.
**摘要**: 研究开发了一种放射性标记的抗CEACAM5抗体(如^89Zr-Df-REA200),用于正电子发射断层扫描(PET)成像。临床试验证实,该探针可高灵敏度检测转移性结直肠癌病灶,为肿瘤分期和治疗监测提供新工具。
如需具体文献来源或补充更多研究,可进一步说明。
CEACAM5 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5), also known as CD66e, is a glycosylphosphatidylinositol (GPI)-anchored membrane protein belonging to the CEACAM family within the immunoglobulin superfamily. Primarily expressed during fetal development, CEACAM5 is typically silenced in most adult tissues but re-emerges as a tumor-associated antigen in various carcinomas, including colorectal, gastric, pancreatic, and lung cancers. Its overexpression in malignancies has made it a valuable biomarker for cancer diagnosis, prognosis, and therapeutic targeting.
Structurally, CEACAM5 contains an N-terminal immunoglobulin variable (IgV)-like domain involved in homophilic and heterophilic interactions, influencing cell adhesion, signaling, and immune modulation. Its role in tumorigenesis includes promoting metastasis, inhibiting apoptosis, and modulating immune evasion by interacting with inhibitory receptors on immune cells.
CEACAM5 antibodies are widely utilized in diagnostics, such as immunohistochemistry (IHC) and serum assays (e.g., ELISA), to detect CEACAM5 expression in tissues or circulating tumor-derived proteins. Therapeutically, anti-CEACAM5 antibodies serve as targeting agents for antibody-drug conjugates (ADCs), bispecific antibodies, and CAR-T cell therapies designed to selectively eliminate CEACAM5-positive cancer cells. Research continues to explore its mechanistic roles in tumor progression and its potential as a predictive biomarker for treatment response. Despite challenges like heterogeneous expression and on-target/off-tumor effects, CEACAM5 remains a focus in oncology research and clinical applications.
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