| WB | 咨询技术 | Human,Mouse,Rat,Rabbit |
| IF | 咨询技术 | Human,Mouse,Rat,Rabbit |
| IHC | 1/200-1/400 | Human,Mouse,Rat,Rabbit |
| ICC | 技术咨询 | Human,Mouse,Rat,Rabbit |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat,Rabbit |
| Elisa | 咨询技术 | Human,Mouse,Rat,Rabbit |
| Aliases | C14orf78 |
| Entrez GeneID | 113146 |
| clone | 21G11B8A12 |
| WB Predicted band size | 61.6kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat,Rabbit |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于AHNAK2抗体的3篇参考文献，包含文献名称、作者及摘要概括：
1. **标题**: *AHNAK2 promotes tumor metastasis by activating the TGF-β signaling pathway in lung adenocarcinoma*
**作者**: Zhang Y, Li X, et al.
**摘要**: 该研究揭示AHNAK2在肺腺癌中高表达，通过激活TGF-β信号通路诱导上皮-间质转化(EMT)，从而促进肿瘤转移。研究利用AHNAK2抗体进行免疫组化验证其临床相关性。
2. **标题**: *AHNAK2 is a novel prognostic biomarker and correlates with immune infiltration in breast cancer*
**作者**: Wang L, Chen J, et al.
**摘要**: 通过分析乳腺癌患者样本，发现AHNAK2高表达与不良预后及肿瘤免疫微环境改变相关。研究采用AHNAK2抗体进行Western blot和免疫荧光，证实其在调控肿瘤细胞迁移中的作用。
3. **标题**: *AHNAK2 interacts with dynein to participate in the repair of nuclear membrane rupture*
**作者**: Benaud C, Le Dez G, et al.
**摘要**: 该文献发现AHNAK2通过与动力蛋白复合物结合，参与细胞核膜损伤修复过程。研究利用特异性AHNAK2抗体进行共聚焦成像，揭示其在细胞应激反应中的动态定位。
(注：上述文献信息为模拟示例，实际引用需以具体检索结果为准。)
The AHNAK2 antibody is a research tool targeting the AHNAK nucleoprotein 2. a large scaffolding protein encoded by the *AHNAK2* gene. AHNAK2. also known as NPHP4. is structurally characterized by a 500 kDa molecular weight and repetitive central domains facilitating interactions with multiple signaling molecules. It plays roles in cell adhesion, cytoskeletal organization, and calcium-dependent signaling, influencing processes like cell migration and tumor metastasis. Dysregulation of AHNAK2 has been linked to cancers (e.g., breast, lung) where it may promote invasiveness, and kidney diseases like nephronophthisis.
AHNAK2 antibodies, typically polyclonal or monoclonal, are generated using recombinant protein fragments or synthetic peptides as immunogens. They are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to detect AHNAK2 expression patterns in tissues or cell lines. Validation often includes knockout controls to confirm specificity.
Research applications focus on elucidating AHNAK2's role in cancer progression, epithelial-mesenchymal transition (EMT), and cilia-related disorders. Its dual association with tumor suppression and metastasis highlights context-dependent functions, making AHNAK2 antibodies critical for exploring its molecular mechanisms and potential as a therapeutic target or biomarker. Commercial suppliers typically provide detailed protocols and specificity data to support experimental reproducibility.
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