Mouse Monoclonal IFNGR1 Antibody

Interferon-gamma receptor 1 (IFNGR1) is a critical component of the interferon-gamma (IFN-γ) signaling pathway, playing a vital role in innate and adaptive immunity. As a transmembrane protein, IFNGR1 forms part of the heterodimeric receptor complex (with IFNGR2) required for IFN-γ binding and downstream activation of the JAK-STAT signaling cascade. This pathway induces antimicrobial, antiproliferative, and immunomodulatory responses, particularly against intracellular pathogens and tumors. Antibodies targeting IFNGR1 are essential tools for studying its expression, function, and dysregulation in diseases. For instance, IFNGR1 mutations are linked to Mendelian Susceptibility to Mycobacterial Diseases (MSMD), a rare immunodeficiency characterized by heightened susceptibility to weakly virulent mycobacteria. Researchers employ monoclonal or polyclonal IFNGR1 antibodies in techniques like flow cytometry, immunohistochemistry, and Western blot to assess receptor expression, localization, or signaling defects in clinical or experimental models. Therapeutic applications are also explored, including neutralizing antibodies to modulate excessive IFN-γ responses in autoimmune disorders or enhance receptor signaling in immunodeficiency contexts. However, challenges remain in balancing specificity and off-target effects. Overall, IFNGR1 antibodies serve as both investigative tools and potential therapeutics, bridging molecular insights into immune dysregulation and clinical interventions.