| WB | 1/500 - 1/2000 | Human, Mouse, Monkey, Rat |
| IF | 咨询技术 | Human, Mouse, Monkey, Rat |
| IHC | 1/200 - 1/1000 | Human, Mouse, Monkey, Rat |
| ICC | 技术咨询 | Human, Mouse, Monkey, Rat |
| FCM | 1/200 - 1/400 | Human, Mouse, Monkey, Rat |
| Elisa | 1/10000 | Human, Mouse, Monkey, Rat |
| Aliases | HPK1 |
| Entrez GeneID | 11184 |
| clone | 5A10F1 |
| WB Predicted band size | 91.3kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Monkey, Rat |
| Immunogen | Purified recombinant fragment of human MAP4K1 (AA:278-477) expressed in mammalian. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于MAP4K1抗体的3篇参考文献示例(注：以下文献信息为虚构示例，实际文献需通过学术数据库检索获取)：
1. **文献名称**：*Targeting MAP4K1 with a novel monoclonal antibody suppresses T cell activation in autoimmune disease models*
**作者**：Chen L, et al.
**摘要**：该研究开发了一种针对MAP4K1的单克隆抗体，证明其可特异性抑制MAP4K1的激酶活性，并显著减少T细胞过度活化，改善实验性自身免疫性脑脊髓炎(EAE)小鼠的病理症状。
2. **文献名称**：*MAP4K1 inhibition via antibody-mediated blockade enhances antitumor immunity in melanoma*
**作者**：Rodriguez JM, et al.
**摘要**：通过抗体靶向抑制MAP4K1.可增强CD8+ T细胞的肿瘤浸润能力，并逆转肿瘤微环境中的免疫抑制状态，显著抑制黑色素瘤小鼠模型的肿瘤生长。
3. **文献名称**：*Structural characterization of MAP4K1 and its interaction with therapeutic antibodies*
**作者**：Wang X, et al.
**摘要**：该研究利用冷冻电镜解析了MAP4K1蛋白的三维结构，并揭示了一种人源化抗体与MAP4K1催化结构域的结合机制，为开发基于抗体的小分子抑制剂提供了结构基础。
如需真实文献，建议在PubMed、Google Scholar等平台检索关键词“MAP4K1 antibody”或“HPK1 therapeutic antibody”。
MAP4K1 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1), also known as HPK1 (Hematopoietic Progenitor Kinase 1), is a serine/threonine kinase belonging to the STE20 family. It plays a critical role in immune regulation, particularly in T-cell receptor (TCR) and B-cell receptor (BCR) signaling pathways. MAP4K1 is involved in modulating T-cell activation, cytokine production, and immune cell survival by regulating downstream effectors like JNK and NF-κB. Its activity influences inflammatory responses and autoimmune diseases, making it a potential therapeutic target.
MAP4K1 antibodies are essential tools for studying its expression, localization, and function in immune cells. They are widely used in techniques such as Western blotting, immunoprecipitation, and immunohistochemistry to investigate MAP4K1’s role in signaling cascades. Researchers also utilize these antibodies to explore MAP4K1’s involvement in cancer immunotherapy, as its inhibition may enhance anti-tumor immunity by reversing T-cell exhaustion. Dysregulation of MAP4K1 has been linked to pathologies like rheumatoid arthritis, lupus, and leukemia, underscoring its biological and clinical relevance.
Current studies focus on developing MAP4K1-targeted therapies, including small-molecule inhibitors and antibody-based approaches, to modulate immune responses in autoimmune disorders and malignancies. Antibodies against MAP4K1 thus serve both as research reagents and potential diagnostic or therapeutic agents in precision medicine.
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