Mouse Monoclonal LRRK2 Antibody

The leucine-rich repeat kinase 2 (LRRK2) antibody is a critical tool for studying LRRK2. a large multidomain protein with kinase and GTPase activities. Mutations in the LRRK2 gene are the most common genetic cause of familial Parkinson’s disease (PD) and are implicated in sporadic PD cases. LRRK2 is involved in cellular processes like membrane trafficking, autophagy, and inflammatory responses, though its precise pathogenic mechanisms remain unclear. Antibodies targeting LRRK2 are widely used in research to detect protein expression, phosphorylation status (e.g., at Ser1292 or Ser935), and cellular localization in tissues or models. They are essential for elucidating LRRK2’s role in neurodegeneration and validating therapeutic strategies, such as kinase inhibitors. However, challenges persist due to LRRK2’s low endogenous expression, structural complexity, and homology with other proteins, which can affect antibody specificity. Commercial LRRK2 antibodies vary in performance across applications (e.g., Western blot, immunohistochemistry), necessitating rigorous validation. Recent efforts focus on developing phospho-specific antibodies to monitor disease-associated hyperactivation (e.g., G2019S mutation) and assess target engagement in clinical trials. Beyond PD, LRRK2 antibodies are also explored in immune-related conditions like Crohn’s disease. Standardizing antibody reproducibility remains a priority to enhance translational research.