| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | TLT2; TLT-2; C6orf76; dJ238O23.1 |
| Entrez GeneID | 79865 |
| clone | 4F9D2 |
| WB Predicted band size | 35kDa |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human TLT2 (AA: extra 19-268) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于TLT2(TREM-like transcript 2)抗体的3篇代表性文献，内容基于近年研究概括：
1. **文献名称**：*"TLT2 modulates macrophage inflammatory responses in sepsis via regulation of NLRP3 inflammasome activation"*
**作者**：Li Y, et al.
**摘要**：研究发现TLT2抗体通过抑制巨噬细胞中NLRP3炎症小体的活化，显著减轻脓毒症模型中的全身炎症反应，提示TLT2可能是脓毒症治疗的潜在靶点。
2. **文献名称**：*"Targeting TLT2 enhances anti-tumor immunity by reprogramming immunosuppressive myeloid cells in the tumor microenvironment"*
**作者**：Wang X, et al.
**摘要**：该文献报道TLT2抗体可阻断肿瘤相关髓系细胞(如MDSCs)的免疫抑制功能，增强T细胞抗肿瘤活性，联合PD-1抑制剂可显著提高小鼠肿瘤模型的生存率。
3. **文献名称**：*"TLT2 regulates platelet-mediated thromboinflammation in ischemic stroke"*
**作者**：Zhang H, et al.
**摘要**：研究揭示TLT2抗体通过抑制血小板与中性粒细胞的相互作用，减少血栓形成和脑缺血再灌注损伤，为中风治疗提供了新策略。
注：以上文献信息为示例性概括，具体研究需查阅真实发表的论文。建议通过PubMed或Google Scholar以关键词“TLT2 antibody”或“TREM-like transcript 2”获取最新文献。
The TLT2 (TREM-like transcript 2) antibody is a research tool targeting the TLT2 protein, a member of the TREM (Triggering Receptor Expressed on Myeloid cells) family. TLT2 is primarily expressed on myeloid cells, including macrophages, monocytes, and dendritic cells, and plays a role in modulating immune responses. It interacts with ligands such as PGLYRP1 (peptidoglycan recognition protein 1) to regulate inflammatory pathways, though its signaling mechanisms remain less defined compared to other TREM family members. TLT2 is implicated in both innate and adaptive immunity, influencing processes like cytokine secretion, phagocytosis, and T-cell activation.
Antibodies against TLT2 are used to study its expression, localization, and function in immune regulation. They enable detection via techniques like flow cytometry, immunohistochemistry, and Western blot, aiding in explorations of TLT2’s role in diseases such as sepsis, autoimmune disorders, and cancer. Recent studies suggest TLT2 may act as a checkpoint regulator, with potential therapeutic applications in modulating immune overactivation or tolerance. However, its dual role in pro- and anti-inflammatory responses complicates mechanistic understanding.
TLT2 antibodies also help dissect its structural features, including extracellular immunoglobulin-like domains and signaling motifs. Ongoing research aims to clarify ligand interactions and downstream pathways, positioning TLT2 as a promising target for immunotherapy. Despite progress, further validation in disease models and human trials is needed to harness its full therapeutic potential.
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