| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50 - 1/200 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | P35; UP3B; UPIIIB |
| Entrez GeneID | 105375355 |
| clone | 3B2G1 |
| WB Predicted band size | 33.8kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human UPK3B (AA: 30-180) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于UPK3B抗体的3篇参考文献的简要总结：
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1. **文献名称**: *Uroplakin 3B is a critical mediator of bladder cancer malignancy via EGFR signaling*
**作者**: Li Y, et al.
**摘要**: 该研究开发了一种特异性识别UPK3B的单克隆抗体，并发现其在膀胱癌组织中高表达。通过该抗体的免疫组化分析，揭示了UPK3B通过激活EGFR信号通路促进肿瘤侵袭的机制。
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2. **文献名称**: *Development of a polyclonal antibody against human UPK3B for urinary exosome detection*
**作者**: Chen X, et al.
**摘要**: 作者报道了一种针对人UPK3B的多克隆抗体的制备及验证。该抗体成功用于尿液外泌体中UPK3B的Western blot及ELISA检测，为膀胱疾病的非侵入性诊断提供了工具。
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3. **文献名称**: *Uroplakin 3B as a biomarker for urothelial carcinoma: Validation using a novel immunohistochemical assay*
**作者**: Wang H, et al.
**摘要**: 研究利用新开发的UPK3B抗体建立免疫组化检测方法，证实UPK3B在尿路上皮癌中的特异性表达，并评估其作为诊断标志物的敏感性和特异性，提示其临床转化潜力。
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注：上述文献信息为示例性内容，实际文献需通过数据库(如PubMed、Web of Science)检索确认。如需具体文章，建议结合关键词“UPK3B antibody”或“uroplakin 3B”进一步筛选。
The uroplacakin 3B (UPK3B) antibody targets a protein belonging to the uroplakin family, which plays a critical role in maintaining the structural integrity and permeability barrier of the urothelium—the specialized epithelial lining of the urinary tract. UPK3B, encoded by the *UPK3B* gene, is a transmembrane protein that forms heterodimers with UPK2A, contributing to the formation of asymmetric unit membranes (AUMs) on the apical surface of urothelial cells. These AUMs are essential for the bladder's ability to withstand urine-derived osmotic stress and prevent pathogen adhesion.
UPK3B is primarily expressed in the urinary bladder, kidneys, and prostate. Its dysregulation has been linked to urological disorders, including bladder cancer, interstitial cystitis, and urinary tract infections. In bladder cancer, altered UPK3B expression may serve as a diagnostic or prognostic biomarker, as its downregulation is often associated with tumor progression and metastasis. Researchers utilize UPK3B antibodies in immunohistochemistry, Western blotting, and immunofluorescence to study urothelial differentiation, disease mechanisms, and therapeutic targets. Additionally, these antibodies aid in distinguishing urothelial carcinomas from other malignancies, given the tissue-specific expression of UPK3B. Ongoing studies explore its role in cellular signaling pathways and interactions with pathogens, underscoring its broader relevance in urological research.
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