首页 / 产品 / 抗体 / 一抗

Mouse Monoclonal ALDH1L1 Antibody

  • 中文名: ALDH1L1抗体
  • 别    名: FDH; FTHFD; 10-fTHF; 10-FTHFDH
货号: IPD32286
Price: ¥1280
数量:
大包装询价

验证与应用

应用及物种
WB 1/500 - 1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/200 - 1/1000 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/200 - 1/400 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

参考文献

以下是关于ALDH1L1抗体的3篇文献摘要示例:

1. **"ALDH1L1 is a tumor suppressor and metabolic enzyme in cancer cells"**

- **作者**: Krupenko, S.A. et al.

- **摘要**: 研究揭示了ALDH1L1作为叶酸代谢关键酶的功能,并通过抗体检测发现其在多种癌细胞中表达下调,表观遗传沉默导致其肿瘤抑制活性丧失。

2. **"Monoclonal antibody characterization of ALDH1L1 in neural stem cells"**

- **作者**: Moffat, J.J. et al.

- **摘要**: 开发了特异性单克隆抗体用于检测ALDH1L1蛋白,发现其在神经干细胞中高表达,可作为神经前体细胞分化的标志物。

3. **"Mitochondrial localization of ALDH1L1 links folate metabolism to oxidative phosphorylation"**

- **作者**: Tian, C. et al.

- **摘要**: 通过免疫荧光和抗体染色技术,证实ALDH1L1定位于线粒体,并调控叶酸代谢与能量生成的关联机制。

(注:以上内容为示例,实际文献需通过学术数据库检索确认。)

背景信息

ALDH1L1 (Aldehyde Dehydrogenase 1 Family Member L1) is a cytosolic enzyme involved in folate metabolism, specifically catalyzing the conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO₂, a critical step in nucleotide synthesis. It is highly expressed in metabolically active tissues, including the liver, kidney, and brain, where it regulates cellular folate homeostasis and redox balance. Structurally, ALDH1L1 contains a formyltransferase domain, an NADP⁺-binding domain, and a hydrolase domain, enabling its multifunctional role. Dysregulation of ALDH1L1 has been linked to cancer, neurodegenerative disorders, and metabolic diseases, with its downregulation observed in various tumors, suggesting potential tumor-suppressive properties.

ALDH1L1 antibodies are essential tools for studying its expression, localization, and function in biological systems. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect ALDH1L1 protein levels in tissues or cell lines. In cancer research, ALDH1L1 antibodies help identify its loss as a biomarker for tumor progression or poor prognosis. In neuroscience, they aid in characterizing astrocyte populations, as ALDH1L1 is a recognized marker of differentiated astrocytes. Both polyclonal and monoclonal antibodies are available, with validation emphasizing specificity across human, mouse, and rat models. Their applications extend to exploring ALDH1L1’s role in oxidative stress response, one-carbon metabolism, and cellular differentiation, making them valuable in diverse biomedical research contexts.

客户数据及评论

折叠内容

大包装询价

×