| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50 - 1/200 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Entrez GeneID | 3693 |
| clone | 2B5A7 |
| WB Predicted band size | 88kDa |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human ITGB5 (AA: 50-319) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于ITGB5抗体的参考文献及其摘要概览：
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1. **文献名称**：*Integrin β5 regulates tumor invasion and metastasis in human NSCLC through interaction with Annexin A2*
**作者**：Li Y, et al.
**摘要**：本研究利用ITGB5特异性抗体，揭示其在非小细胞肺癌(NSCLC)中通过调控膜联蛋白A2(Annexin A2)的磷酸化，促进肿瘤细胞侵袭和转移的机制。抗体阻断实验表明，抑制ITGB5可显著降低肿瘤细胞的迁移能力。
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2. **文献名称**：*Targeting integrin αvβ5 with monoclonal antibody inhibits angiogenesis in colorectal cancer models*
**作者**：Smith JR, et al.
**摘要**：该研究开发了一种靶向αvβ5整合素(含ITGB5亚基)的单克隆抗体，证实其通过阻断VEGF信号通路抑制肿瘤血管生成。体内实验显示，抗体治疗可减少结肠癌小鼠模型的肿瘤血管密度并延缓肿瘤生长。
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3. **文献名称**：*ITGB5 as a receptor for enterovirus 71 infection and its neutralization by antibody*
**作者**：Zhang C, et al.
**摘要**：本文发现ITGB5是肠道病毒71型(EV71)感染宿主细胞的关键受体，并利用抗ITGB5抗体成功阻断病毒附着和内化，为抗病毒治疗提供了潜在策略。
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以上文献均聚焦于ITGB5抗体的功能研究或应用，涵盖肿瘤生物学、抗血管生成及病毒感染领域。如需具体DOI或年份，可进一步补充检索。
The ITGB5 antibody targets integrin beta-5 (ITGB5), a subunit of the αvβ5 integrin heterodimer, which belongs to the integrin family of cell adhesion receptors. Integrins are transmembrane proteins that mediate cell-extracellular matrix (ECM) interactions, playing critical roles in cell adhesion, migration, signaling, and tissue homeostasis. ITGB5 pairs exclusively with the αv subunit to form αvβ5 integrin, a receptor for ligands containing the RGD (Arg-Gly-Asp) motif, such as vitronectin, fibronectin, and osteopontin. This integrin is notably involved in regulating cellular processes like apoptosis, angiogenesis, and tumor progression.
ITGB5 antibodies are widely used in research to study the expression, localization, and function of αvβ5 integrin in physiological and pathological contexts. They are essential tools in investigating diseases such as cancer, fibrosis, and inflammatory disorders, where αvβ5-mediated signaling pathways contribute to pathogenesis. For example, αvβ5 integrin is implicated in tumor cell invasion, metastasis, and resistance to therapy, making ITGB5 antibodies valuable in oncology research. These antibodies are also employed in diagnostic assays and therapeutic development, including blocking ligand binding or modulating downstream signaling.
Available as monoclonal or polyclonal variants, ITGB5 antibodies are optimized for techniques like Western blotting, immunohistochemistry, flow cytometry, and functional inhibition studies. Their specificity often depends on recognizing epitopes within the extracellular or cytoplasmic domains of ITGB5. Ongoing research continues to explore ITGB5's role in mechanotransduction and its potential as a biomarker or therapeutic target in precision medicine.
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