| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | FRA |
| Entrez GeneID | 79874 |
| clone | 2B2A6 |
| WB Predicted band size | 63.5kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human RABEP2 (AA: 10-200) expressed in HEK293-6e cells supernatant. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
+ +
以下是关于RABEP2抗体的参考文献示例(注：以下内容为假设性示例，实际文献需通过学术数据库核实)：
---
1. **标题**: *RABEP2 regulates endosomal trafficking and promotes cancer cell invasion*
**作者**: Chen L, et al. (2021)
**摘要**: 本研究通过抗RABEP2抗体的Western blot和免疫荧光技术，揭示了RABEP2在乳腺癌细胞中调控内体运输的功能，并发现其高表达与细胞侵袭性增强相关。
2. **标题**: *RABEP2 modulates synaptic vesicle recycling in neuronal cells*
**作者**: Müller S, et al. (2019)
**摘要**: 利用抗RABEP2抗体的免疫共沉淀和免疫组化实验，证实RABEP2通过结合Rab GTPases调控突触囊泡循环，影响神经元信号传递。
3. **标题**: *RABEP2 deficiency disrupts glucose metabolism via impaired GLUT4 trafficking*
**作者**: Tanaka K, et al. (2017)
**摘要**: 在小鼠模型中，通过抗RABEP2抗体的组织染色和蛋白质分析，发现RABEP2缺失导致GLUT4转运异常，进而影响胰岛素介导的葡萄糖摄取。
4. **标题**: *Characterization of a novel RABEP2 monoclonal antibody for diagnostic applications*
**作者**: Gupta R, et al. (2020)
**摘要**: 本文描述了一种新型抗RABEP2单克隆抗体的开发与验证，证明其在结直肠癌组织中的高特异性，适用于临床病理诊断。
---
**建议**：实际文献请通过PubMed、Google Scholar等平台检索关键词“RABEP2 antibody”或“RABEP2 function”，并筛选涉及抗体应用的实验研究。部分商业抗体供应商(如Abcam、Thermo Fisher)的产品页面也可能引用相关文献。
The RABEP2 (Rab GTPase-binding effector protein 2) antibody is a tool used to study the function and expression of the RABEP2 protein, a member of the Rab effector family. RABEP2. also known as rabaptin-5β, interacts with Rab GTPases, particularly Rab5 and Rab4. which regulate endosomal trafficking and membrane receptor recycling. It shares homology with rabaptin-5 but exhibits distinct tissue expression patterns, with higher levels in the brain, suggesting roles in neuronal vesicle transport or synaptic function.
RABEP2 is implicated in endosome maturation, receptor sorting, and autophagy. Dysregulation of RABEP2 has been linked to diseases, including cancers (e.g., colorectal, breast) and neurodevelopmental disorders. For instance, altered RABEP2 expression may influence tumor progression via aberrant receptor tyrosine kinase signaling or disrupted vesicle trafficking. In neuroscience, RABEP2 variants are associated with intellectual disability and autism spectrum disorders, possibly through impaired synaptic vesicle dynamics.
The RABEP2 antibody enables detection and localization of the protein in cells and tissues via techniques like Western blot, immunohistochemistry, and immunofluorescence. Researchers use it to explore RABEP2's role in cellular pathways, disease mechanisms, and its potential as a biomarker or therapeutic target. Commercial antibodies are typically validated for specificity, often targeting unique epitopes within its N-terminal or coiled-coil domains. Ongoing studies aim to clarify its precise molecular interactions and pathophysiological relevance.
×
