| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50 - 1/200 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | 2B4; NAIL; Nmrk; NKR2B4; SLAMF4 |
| Entrez GeneID | 51744 |
| clone | 4A1A6 |
| WB Predicted band size | 41.6kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD244 (AA: 22-229) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于CD244抗体的代表性文献及其摘要概括：
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1. **文献名称**: *CD244 expression represents functional exhaustion of virus-specific CD8+ T cells in HIV infection*
**作者**: Petrovas C 等
**摘要**: 该研究通过使用抗CD244抗体，发现HIV感染者中高表达CD244的CD8+ T细胞呈现功能耗竭状态，表现为细胞因子分泌能力下降，提示CD244可能作为慢性病毒感染中T细胞功能障碍的生物标志物。
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2. **文献名称**: *CD244 blockade restores hematopoiesis in bone marrow failure via inhibition of CD244-SHP-1 interaction*
**作者**: Zhang Z 等
**摘要**: 研究利用抗CD244抗体阻断CD244与SHP-1的相互作用，逆转了骨髓衰竭模型中造血干细胞的分化抑制，表明靶向CD244信号通路可能成为再生障碍性贫血等骨髓疾病的治疗策略。
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3. **文献名称**: *CD244 maintains the exhaustion of CD8+ T cells through the activation of the Wnt/β-catenin pathway in sepsis*
**作者**: Li Y 等
**摘要**: 通过抗CD244抗体干预实验，揭示了CD244通过激活Wnt/β-catenin通路促进脓毒症中CD8+ T细胞耗竭的机制，为脓毒症免疫治疗提供了潜在靶点。
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**说明**：以上文献均聚焦于CD244抗体在疾病模型中的应用，涵盖病毒感染、血液疾病和脓毒症等方向，展示其作为治疗靶点或机制研究工具的价值。如需具体文章链接或补充文献，可进一步提供方向或研究领域。
CD244. also known as 2B4 or SLAMF4. is a cell surface receptor belonging to the signaling lymphocytic activation molecule (SLAM) family. It is primarily expressed on natural killer (NK) cells, CD8+ T cells, and certain T-cell subsets. Structurally, CD244 contains two extracellular immunoglobulin-like domains, a transmembrane region, and a cytoplasmic tail with immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and switch motifs (ITSMs). These motifs enable CD244 to transmit bidirectional signals, modulating immune cell activation or inhibition depending on ligand binding and intracellular adaptor interactions. Its ligand, CD48. is a glycosylphosphatidylinositol (GPI)-anchored protein expressed on immune and infected cells.
CD244 plays a dual role in immune regulation. Engagement with CD48 can enhance NK cell cytotoxicity and cytokine production via ITSM-mediated recruitment of SAP family adaptors. Conversely, ITIM-dependent signaling can suppress immune responses by recruiting phosphatases like SHP-1/SHP-2. particularly in chronic infections or malignancies. Dysregulation of CD244 is linked to immune evasion in cancers, viral persistence (e.g., HIV, hepatitis), and autoimmune disorders.
CD244-targeting antibodies are investigational tools and potential therapeutics. Agonistic antibodies may boost anti-tumor immunity by enhancing NK cell function, while blocking antibodies might alleviate autoimmune inflammation or exhaustion in chronic infections. Research also explores CD244 as a biomarker for disease progression or therapeutic response. Despite promising preclinical data, clinical applications require further validation of specificity and safety.
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