| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | HO-1; HSP32; HMOX1D; bK286B10 |
| Entrez GeneID | 3162 |
| clone | 2B2A1 |
| WB Predicted band size | 32.8kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human HMOX1 (AA: 1-110) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于HMOX1抗体的3篇文献示例(内容为虚构，仅供参考格式)：
1. **"HMOX1 Antibody-Based Detection of Oxidative Stress in Murine Models of Alzheimer's Disease"**
- 作者：Kim, J. et al.
- 摘要：研究使用HMOX1特异性抗体，通过免疫组化技术检测阿尔茨海默病模型小鼠脑组织中HMOX1蛋白的表达，发现其表达水平与β-淀粉样斑块沉积呈正相关，提示HMOX1在神经退行性病变中的抗氧化保护作用。
2. **"A Novel Monoclonal Antibody for HMOX1 Reveals Its Role in Diabetic Nephropathy"**
- 作者：Chen, L. & Patel, R.
- 摘要：开发一种高特异性抗HMOX1单克隆抗体，用于Western blot和流式细胞术分析，证实糖尿病肾病模型中肾小管上皮细胞的HMOX1上调，与炎症因子IL-6的释放密切相关。
3. **"HMOX1 Antibody Application in Hepatic Ischemia-Reperfusion Injury Studies"**
- 作者：Gomez, S. et al.
- 摘要：通过HMOX1抗体免疫荧光染色，发现肝脏缺血再灌注损伤后，HMOX1在Kupffer细胞中显著激活，其表达动态变化与组织氧化损伤程度相关，为靶向HMOX1的治疗策略提供依据。
(注：以上文献为示例，实际引用需检索PubMed等数据库获取真实研究。)
HMOX1 (heme oxygenase 1) is a stress-responsive enzyme encoded by the HMOX1 gene, which catalyzes the breakdown of heme into biliverdin, carbon monoxide, and free iron. This process plays a critical role in cellular defense against oxidative stress, inflammation, and apoptosis. HMOX1 is induced by various stimuli, including reactive oxygen species (ROS), heavy metals, hypoxia, and inflammatory cytokines, primarily through the activation of the Nrf2-Keap1 signaling pathway. Its expression is associated with antioxidant, anti-inflammatory, and cytoprotective functions, making it a key biomarker in studies of oxidative damage, aging, and diseases like cancer, neurodegenerative disorders, and cardiovascular conditions.
HMOX1 antibodies are essential tools for detecting and quantifying HMOX1 protein levels in research. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and ELISA to investigate HMOX1's regulation, localization, and role in disease mechanisms. Most commercially available HMOX1 antibodies are raised against specific epitopes of human or mouse HMOX1. with rabbit or mouse-derived monoclonal or polyclonal variants. Validation includes testing for cross-reactivity and specificity across species. Researchers rely on HMOX1 antibodies to explore therapeutic strategies targeting oxidative stress pathways, evaluate drug efficacy, or study tissue-specific responses to injury. However, variability in antibody performance under different experimental conditions necessitates careful optimization and controls.
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