| WB | 1/500 - 1/2000 | Human, Mouse, Rat, Monkey |
| IF | 咨询技术 | Human, Mouse, Rat, Monkey |
| IHC | 1/200 - 1/1000 | Human, Mouse, Rat, Monkey |
| ICC | 技术咨询 | Human, Mouse, Rat, Monkey |
| FCM | 1/200 - 1/400 | Human, Mouse, Rat, Monkey |
| Elisa | 1/10000 | Human, Mouse, Rat, Monkey |
| Aliases | TM-8; TM4-B; TM4SF16 |
| Entrez GeneID | 26526 |
| clone | 5A2C10 |
| WB Predicted band size | 26.2kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat, Monkey |
| Immunogen | Purified recombinant fragment of human TSPAN16 (AA: 116-245) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3-4条关于TSPAN16抗体的虚构参考文献示例(基于常见研究方向概括，非真实文献)：
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1. **文献名称**: "TSPAN16 expression in gastric cancer and its association with prognosis"
**作者**: Li X, Wang Y, Zhang H.
**摘要**: 本研究通过免疫组化(IHC)和Western blot(WB)检测TSPAN16抗体在胃癌组织中的表达，发现TSPAN16高表达与患者不良预后及淋巴结转移显著相关，提示其可能作为胃癌潜在生物标志物。
2. **文献名称**: "Functional characterization of TSPAN16 in leukemia cell proliferation"
**作者**: Smith J, Brown K, Lee M.
**摘要**: 利用TSPAN16特异性抗体进行蛋白质敲低实验，发现抑制TSPAN16可显著降低白血病细胞系(如K562)的增殖能力，并诱导细胞周期阻滞，表明TSPAN16在白血病发生中起关键作用。
3. **文献名称**: "TSPAN16 interacts with EGFR to modulate signaling pathways in lung adenocarcinoma"
**作者**: Chen L, Zhou R, Liu F.
**摘要**: 通过免疫共沉淀(Co-IP)结合TSPAN16抗体，证实TSPAN16与EGFR存在直接相互作用，促进MAPK/ERK通路活化，进而增强肺癌细胞迁移和侵袭能力。
4. **文献名称**: "TSPAN16 antibody-based detection in colorectal cancer progression"
**作者**: Tanaka S, Yamamoto T, Sato A.
**摘要**: 采用TSPAN16多克隆抗体分析结直肠癌患者样本，发现TSPAN16在转移性肿瘤中表达上调，并通过体外实验证明其通过调控Wnt/β-catenin通路促进EMT过程。
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注：以上为模拟内容，实际文献需通过PubMed/Google Scholar等平台检索确认。
The TSPAN16 antibody is a research tool designed to detect and study the Tetraspanin 16 (TSPAN16) protein, a member of the tetraspanin family. Tetraspanins are transmembrane proteins characterized by four conserved transmembrane domains, which organize membrane microdomains and mediate cell-cell interactions, signaling, and adhesion. TSPAN16. also known as TM4-B, is encoded by the TSPAN16 gene located on human chromosome 17q21.2. While its specific biological roles remain under investigation, TSPAN16 is believed to participate in cellular processes such as membrane organization, protein trafficking, and possibly immune regulation. It is expressed in various tissues, including the brain, liver, and immune cells.
Antibodies targeting TSPAN16 are typically developed in animal hosts (e.g., rabbits or mice) using immunogenic peptides or recombinant protein fragments. These antibodies enable the detection of TSPAN16 in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Validation often includes specificity tests using knockout cell lines or tissues. Research involving TSPAN16 antibodies has explored its potential roles in cancer, where altered expression has been observed in certain malignancies, and neurological disorders. However, comprehensive functional studies are still needed to clarify its exact mechanisms and therapeutic relevance. As such, TSPAN16 antibodies serve as critical tools for elucidating the protein's physiological and pathological contributions.
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