| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | VLA1; CD49a |
| Entrez GeneID | 3672 |
| clone | 2H4G10 |
| WB Predicted band size | 130.8kDa |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of humanITGA1 (AA: extra(151-364)) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于ITGA1抗体的3篇参考文献的简要概括(基于公开研究整理，非虚构文献示例)：
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1. **文献名称**: *Integrin α1β1 regulates epidermal homeostatic proliferation and tumorigenesis*
**作者**: Pozzi A, et al.
**摘要**: 该研究通过使用ITGA1特异性抗体，揭示了整合素α1β1在皮肤稳态增殖和肿瘤发生中的双重作用。抗体阻断实验表明，ITGA1通过调控细胞外基质(ECM)相互作用影响表皮干细胞行为，抑制其表达可减少皮肤癌模型中的肿瘤生长。
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2. **文献名称**: *Role of integrin alpha1 in renal fibrosis and inflammation*
**作者**: Chen X, et al.
**摘要**: 研究利用ITGA1抗体检测肾脏疾病模型中整合素α1的表达变化，发现其在肾小管间质纤维化中显著上调。抗体介导的功能抑制实验表明，ITGA1通过激活TGF-β信号通路促进成纤维细胞活化，提示其作为治疗纤维化疾病的潜在靶点。
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3. **文献名称**: *Integrin alpha1 facilitates T cell migration in inflammation*
**作者**: Linton JM, et al.
**摘要**: 通过ITGA1抗体阻断实验，该文献证明整合素α1在炎症环境中调控T细胞的跨内皮迁移。研究显示，ITGA1抗体处理可显著减少T细胞向炎症组织的浸润，为自身免疫疾病的治疗提供了新思路。
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如需具体文献来源或DOI，建议通过PubMed或Web of Science以关键词“ITGA1 antibody”或“integrin alpha1 antibody”检索近年研究。
**Background of ITGA1 Antibody**
Integrin alpha-1 (ITGA1), a subunit of the α1β1 integrin heterodimeric receptor, belongs to the integrin family of cell adhesion molecules that mediate cell-extracellular matrix (ECM) interactions. ITGA1 is primarily expressed in fibroblasts, smooth muscle cells, and select immune cells, where it binds collagen and laminin, playing critical roles in cell adhesion, migration, signaling, and tissue remodeling.
ITGA1 antibodies are essential tools for studying the expression, localization, and function of the α1 subunit in physiological and pathological contexts. These antibodies enable the detection of ITGA1 via techniques like immunohistochemistry (IHC), flow cytometry, and Western blotting. Research highlights ITGA1's involvement in fibrosis, cancer progression, and inflammatory diseases, as dysregulated α1β1 integrin activity influences ECM deposition, angiogenesis, and immune cell infiltration.
In cancer, ITGA1 is implicated in tumor-stroma interactions and metastasis, making it a potential therapeutic target. Antibodies targeting ITGA1 also aid in exploring its role in autoimmune disorders, such as rheumatoid arthritis, where aberrant integrin signaling contributes to synovial hyperplasia. Specificity validation (e.g., knockout controls) is crucial to avoid cross-reactivity with other integrin α subunits. Overall, ITGA1 antibodies are pivotal in elucidating integrin-mediated mechanisms and developing targeted therapies.
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