| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | VLA1; CD49a |
| Entrez GeneID | 3672 |
| clone | 5F9H10 |
| WB Predicted band size | 130.8kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of humanITGA1 (AA: extra(151-364)) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于ITGA1抗体的3篇模拟参考文献(基于研究领域常见主题，非真实文献)：
1. **文献名称**：*"ITGA1 Antibody-Based Targeting of Collagen Remodeling in Fibrotic Diseases"*
**作者**：Kim, H. et al.
**摘要**：研究利用ITGA1特异性抗体抑制胶原结合活性，发现其在肺纤维化模型中可减少细胞外基质沉积，提示ITGA1可能成为抗纤维化治疗的靶点。
2. **文献名称**：*"Role of ITGA1 in Tumor Angiogenesis: Insights from Antibody Blockade Experiments"*
**作者**：Chen, L. et al.
**摘要**：通过ITGA1抗体阻断肿瘤血管内皮细胞的整合素信号，发现其显著抑制小鼠模型中肿瘤血管生成，表明ITGA1在肿瘤微环境中的关键作用。
3. **文献名称**：*"ITGA1 Expression in Inflammatory Bowel Disease: An Immunohistochemical Study"*
**作者**：Müller, S. et al.
**摘要**：采用ITGA1抗体进行组织染色，揭示其在肠道炎症区域的异常高表达，提示ITGA1可能参与肠道屏障功能障碍的病理机制。
4. **文献名称**：*"Development of a High-Affinity Anti-ITGA1 Monoclonal Antibody for Functional Studies"*
**作者**：Rodriguez, A. et al.
**摘要**：报道了一种新型抗ITGA1单克隆抗体的开发，验证了其在流式细胞术和免疫沉淀中的特异性，并用于研究ITGA1在成纤维细胞迁移中的作用。
(注：以上文献为模拟示例，实际引用请通过PubMed或Google Scholar检索关键词“ITGA1 antibody”获取具体研究。)
The ITGA1 antibody targets integrin alpha-1 (ITGA1), a subunit of the α1β1 integrin heterodimer, part of the integrin family of cell adhesion receptors. Integrins mediate bidirectional signaling between cells and the extracellular matrix (ECM), influencing cell migration, proliferation, and survival. ITGA1 pairs exclusively with β1 (ITGB1) to form α1β1. a collagen/laminin receptor predominantly expressed in fibroblasts, smooth muscle cells, and certain immune cells. It plays critical roles in tissue development, wound healing, and angiogenesis by regulating ECM remodeling and cell-ECM interactions.
In research, ITGA1 antibodies are essential tools for detecting protein expression, localization, and function via techniques like immunohistochemistry (IHC), flow cytometry, and Western blotting. These antibodies help elucidate ITGA1's involvement in pathological processes, including fibrosis, cancer progression, and inflammatory diseases. For instance, ITGA1 upregulation correlates with tumor invasiveness in some cancers, while its dysregulation is linked to aberrant collagen deposition in fibrotic disorders. Additionally, studies explore ITGA1 as a potential therapeutic target, with blocking antibodies tested in preclinical models to inhibit pathogenic cell adhesion or signaling.
Available as monoclonal or polyclonal formats, ITGA1 antibodies vary in species reactivity (e.g., human, mouse, rat) and applications, requiring validation for specificity. Their utility spans basic research to translational studies, contributing to understanding integrin-mediated mechanisms in health and disease.
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