Mouse Monoclonal KCNN4 Antibody

The KCNN4 antibody targets the KCNN4 protein, also known as potassium calcium-activated channel subfamily N member 4 or KCa3.1/SK4. This protein is a calcium-activated potassium channel that plays a critical role in regulating membrane potential and calcium signaling in various cell types, including immune cells (e.g., T cells, macrophages), epithelial cells, and endothelial cells. KCNN4 facilitates potassium efflux upon intracellular calcium elevation, influencing cellular processes like proliferation, migration, and secretion. Its dysfunction is linked to pathologies such as inflammation, cancer progression, fibrosis, and sickle cell disease. Antibodies against KCNN4 are widely used in research to detect its expression and localization via techniques like Western blotting, immunohistochemistry, and flow cytometry. These tools help elucidate KCNN4's physiological roles and its potential as a therapeutic target, particularly since KCa3.1 inhibitors (e.g., TRAM-34) show promise in preclinical models for autoimmune disorders and fibrotic diseases. The antibody's specificity and reliability are crucial for advancing studies on channel biology and developing targeted therapies.