| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | GCAP; ALPPL; ALPPL2 |
| Entrez GeneID | 251 |
| clone | 3C5A7 |
| WB Predicted band size | 57.3kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human ALPG (AA: 170-285) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于ALPG抗体的3篇参考文献摘要示例：
1. **文献名称**: "Placental alkaline phosphatase (ALPP) as a biomarker for cervical cancer progression"
**作者**: Zhang Y, et al.
**摘要**: 研究通过免疫组化分析ALPP在宫颈癌组织中的表达，发现其高表达与肿瘤侵袭性和不良预后相关，提示ALPP抗体可作为潜在诊断标志物。
2. **文献名称**: "Targeting ALPG with monoclonal antibodies inhibits ovarian cancer cell growth in vitro"
**作者**: Lee S, et al.
**摘要**: 开发针对ALPG的单克隆抗体，体外实验证实其能特异性结合卵巢癌细胞并抑制增殖，为靶向治疗提供新策略。
3. **文献名称**: "ALPG expression profiling in colorectal cancer and its association with chemotherapy resistance"
**作者**: Müller J, et al.
**摘要**: 利用ALPG抗体检测结直肠癌样本，发现ALPG高表达患者对5-FU化疗耐药性显著增强，机制可能与Wnt信号通路激活相关。
4. **文献名称**: "Epigenetic regulation of ALPG in hepatocellular carcinoma and its clinical implications"
**作者**: Wang X, et al.
**摘要**: 研究ALPG在肝癌中的表观遗传调控，通过抗体检测发现启动子低甲基化导致ALPG过表达，且与患者生存率下降及血管浸润相关。
注：以上文献为示例性质，实际引用时请核实具体研究内容及来源可靠性。
**Background of ALPG Antibody**
ALPG (alkaline phosphatase, placental/germ cell-like) is a glycosylphosphatidylinositol (GPI)-anchored enzyme encoded by the *ALPP* gene. It belongs to the alkaline phosphatase (ALP) family, which catalyzes the hydrolysis of phosphate esters in alkaline conditions. ALPG is primarily expressed in placental trophoblasts during pregnancy and is involved in nutrient transport and cellular differentiation. It is also termed placental alkaline phosphatase (PLAP) due to its predominant association with placental tissue.
Beyond its physiological role, ALPG is re-expressed in certain cancers, including germ cell tumors (e.g., testicular and ovarian cancers) and some epithelial malignancies (e.g., lung, gastrointestinal). This ectopic expression makes ALPG a valuable tumor marker for diagnosis, prognosis, and monitoring therapeutic responses.
ALPG antibodies are immunological tools designed to detect and quantify ALPG protein levels in tissues or biological fluids. These antibodies are widely used in immunohistochemistry (IHC), enzyme-linked immunosorbent assays (ELISA), and Western blotting to study ALPG’s distribution, overexpression in malignancies, or placental function. Specificity and sensitivity of ALPG antibodies are critical for distinguishing ALPG from other ALP isoforms (e.g., intestinal or liver ALP) in diagnostic applications.
Research on ALPG antibodies also explores their therapeutic potential, such as antibody-drug conjugates (ADCs) targeting ALPG-positive cancers. Overall, ALPG antibodies serve as essential reagents in both biomedical research and clinical diagnostics.
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