| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | FRA |
| Entrez GeneID | 79874 |
| clone | 2B1B6 |
| WB Predicted band size | 63.5kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human RABEP2 (AA: 10-200) expressed in HEK293-6e cells supernatant. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于RABEP2抗体的3篇假设性参考文献示例(请注意，这些为模拟内容，实际文献需通过学术数据库查询)：
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1. **文献名称**：*RABEP2 regulates endosomal trafficking and promotes breast cancer cell invasion*
**作者**：Smith A, et al.
**摘要**：本研究利用RABEP2抗体进行免疫印迹和免疫荧光实验，发现RABEP2通过调控早期内体运输促进乳腺癌细胞的迁移和侵袭，提示其作为潜在治疗靶点。
2. **文献名称**：*Characterization of RABEP2 antibody specificity in neuronal development*
**作者**：Chen L, et al.
**摘要**：文章验证了RABEP2抗体的特异性，并发现RABEP2在小鼠大脑皮层神经元发育中参与突触囊泡运输，影响神经信号传递。
3. **文献名称**：*RABEP2 interacts with Rab5 GTPase to modulate EGFR recycling*
**作者**：Yamamoto K, et al.
**摘要**：通过免疫共沉淀(使用RABEP2抗体)和功能分析，揭示RABEP2与Rab5的相互作用调控表皮生长因子受体(EGFR)的再循环，影响细胞增殖。
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如需真实文献，建议在 **PubMed** 或 **Google Scholar** 中搜索关键词“RABEP2 antibody”或“RABEP2 function”，并筛选近年研究。部分研究可能聚焦于抗体开发或疾病机制。
The Rab GTPase effector protein RABEP2 (Rabaptin-5-like) is a peripheral membrane protein involved in regulating endocytic trafficking and membrane dynamics. It interacts with Rab GTPases, particularly Rab4 and Rab5. to mediate vesicle fusion and receptor sorting in early endosomes. RABEP2 is structurally related to Rabaptin-5 but exhibits distinct functional roles, including modulating epidermal growth factor receptor (EGFR) recycling and lysosomal degradation pathways. Dysregulation of RABEP2 has been implicated in cancer progression, neurological disorders, and metabolic diseases, though its precise mechanisms remain under investigation.
RABEP2 antibodies are immunological tools used to detect, quantify, or visualize RABEP2 protein expression in research. They enable studies on its subcellular localization, interaction partners, and expression patterns across tissues. Commonly validated through techniques like Western blotting, immunofluorescence, and immunoprecipitation, these antibodies help elucidate RABEP2's role in vesicular transport, autophagy, and disease pathophysiology. Commercial RABEP2 antibodies are typically raised in rabbits or mice using synthetic peptides or recombinant protein fragments. Specificity and batch consistency are critical considerations, as cross-reactivity with homologous proteins (e.g., Rabaptin-5) may occur. Recent studies using RABEP2 antibodies have highlighted its potential as a biomarker in certain cancers and neurodegenerative conditions.
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