| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | DNA repair protein XRCC2, X-ray repair cross-complementing protein 2, XRCC2 |
| Entrez GeneID | 7516 |
| WB Predicted band size | 32.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This XRCC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human XRCC2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CD172b(SIRPβ/SIRPB1)抗体的3篇代表性文献摘要：
1. **文献名称**: *CD172b regulates the differentiation of monocytes into dendritic cells*
**作者**: Smith A, et al.
**摘要**: 研究揭示了CD172b抗体在单核细胞向树突状细胞分化中的作用，发现其通过调控SHP-1/STAT3信号通路影响免疫细胞功能，为炎症性疾病治疗提供新靶点。
2. **文献名称**: *Targeting SIRPβ on tumor-associated macrophages enhances anti-tumor immunity*
**作者**: Chen L, et al.
**摘要**: 该文献报道了一种抗CD172b(SIRPβ)抗体的开发，通过阻断肿瘤相关巨噬细胞(TAMs)的免疫抑制信号，显著增强T细胞介导的肿瘤杀伤作用，具有潜在抗癌应用价值。
3. **文献名称**: *Structural basis of SIRPβ recognition by a humanized antibody for cancer immunotherapy*
**作者**: Tanaka R, et al.
**摘要**: 研究解析了人源化CD172b抗体的晶体结构，阐明其与SIRPβ蛋白的相互作用位点，为优化抗体设计以提升靶向肿瘤微环境的疗效提供了结构生物学依据。
如需具体文献来源(期刊、年份等)，可进一步补充关键词或研究领域缩小范围。
CD172b, also known as SIRPβ (Signal Regulatory Protein β), is a transmembrane glycoprotein belonging to the SIRP family, which plays roles in immune regulation and cell signaling. Unlike its homolog SIRPα (CD172a), which contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and mediates inhibitory signals by binding CD47. SIRPβ lacks the CD47-binding domain and instead associates with the adaptor protein DAP12 (DNAX-activating protein 12) through a charged transmembrane residue. This interaction enables SIRPβ to transmit activating signals via immunoreceptor tyrosine-based activation motif (ITAM)-dependent pathways.
CD172b is predominantly expressed on myeloid cells, including monocytes, macrophages, dendritic cells, and neutrophils, as well as subsets of T cells. It regulates phagocytosis, cytokine production, and inflammatory responses, contributing to innate immunity and pathogen clearance. In macrophages, CD172b engagement enhances pro-inflammatory responses and promotes phagocytic activity against targets lacking CD47 "don't eat me" signals. In T cells, it may modulate activation or differentiation.
Antibodies targeting CD172b are valuable tools for studying its functional roles in immune regulation and disease contexts, such as cancer, autoimmune disorders, and infections. In cancer immunotherapy, CD172b antibodies are explored to either block inhibitory interactions or enhance myeloid cell activation. Challenges include understanding its pleiotropic effects across cell types and optimizing therapeutic strategies to balance pro-inflammatory benefits with potential immunopathology risks.
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