| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | SELP; CD62; GRMP; PSEL; GMP140; LECAM3; PADGEM |
| Entrez GeneID | 6403 |
| clone | 5E1B12 |
| WB Predicted band size | 90.8kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD62P (AA: extra 42-208) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD62P(P-selectin)抗体的3篇文献摘要示例(注：文献信息为虚拟概括，非真实引用)：
1. **文献名称**：*P-selectin-dependent platelet aggregation in thrombosis*
**作者**：Smith A, et al.
**摘要**：该研究利用CD62P抗体检测血小板活化状态，揭示P-selectin在动脉血栓形成中促进血小板-白细胞相互作用，为抗血栓治疗提供靶点。
2. **文献名称**：*CD62P as a biomarker for sepsis-induced coagulopathy*
**作者**：Zhang L, et al.
**摘要**：通过流式细胞术结合CD62P抗体，发现脓毒症患者血小板表面P-selectin表达显著升高，提示其可作为凝血功能紊乱的早期诊断标志物。
3. **文献名称**：*Anti-CD62P antibody inhibits cancer metastasis*
**作者**：Chen R, et al.
**摘要**：实验证明，阻断性CD62P抗体可通过抑制肿瘤细胞与血管内皮粘附，减少肿瘤转移灶形成，为抗肿瘤治疗提供新策略。
(如需真实文献，建议在PubMed或Web of Science中检索关键词“CD62P antibody/P-selectin antibody”)
CD62P, also known as P-selectin, is a transmembrane glycoprotein belonging to the selectin family of cell adhesion molecules. It is primarily expressed on activated platelets and endothelial cells, stored in α-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cellular activation by inflammatory cytokines, thrombin, or other stimuli, CD62P is rapidly translocated to the cell surface, where it mediates leukocyte rolling and adhesion by binding to PSGL-1 (P-selectin glycoprotein ligand-1) on leukocytes. This interaction plays a critical role in thrombosis, inflammation, and atherosclerosis.
CD62P antibodies are widely used as biomarkers to detect platelet activation or endothelial dysfunction in research and clinical settings. In flow cytometry, anti-CD62P antibodies help identify activated platelets in cardiovascular diseases, sepsis, or immune disorders. They are also employed in immunohistochemistry and functional studies to investigate leukocyte-endothelial interactions. Therapeutic targeting of CD62P with monoclonal antibodies or inhibitors has been explored to attenuate pathological inflammation and thrombotic events, though no approved therapies currently exist. Due to its transient expression and specificity for activated cells, CD62P remains a key focus in vascular biology and hematology research.
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