| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | SELP; CD62; GRMP; PSEL; GMP140; LECAM3; PADGEM |
| Entrez GeneID | 6403 |
| clone | 7A3D9 |
| WB Predicted band size | 90.8kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD62P (AA: extra 42-208) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD62P(P-选择素)抗体的参考文献示例(内容为模拟概括，仅供参考)：
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1. **文献名称**: *"P-Selectin-Dependent Platelet Aggregation in Thrombosis: Role of CD62P Antibody Blockade"*
**作者**: Smith J, et al.
**摘要**: 该研究探讨了抗CD62P抗体通过抑制P-选择素与白细胞表面配体结合，减少血小板-白细胞聚集，从而降低动脉血栓形成的风险，为抗血栓治疗提供了新策略。
2. **文献名称**: *"CD62P as a Biomarker for Platelet Activation in Sepsis: Validation by Monoclonal Antibody-Based Assays"*
**作者**: Lee H, et al.
**摘要**: 研究利用抗CD62P单克隆抗体建立流式细胞术检测方法，证实脓毒症患者血小板活化水平显著升高，提示CD62P可作为炎症性疾病的诊断标志物。
3. **文献名称**: *"Targeting P-Selectin with Antibodies Inhibits Cancer Metastasis in Preclinical Models"*
**作者**: Zhang R, et al.
**摘要**: 通过动物实验证明，抗CD62P抗体可阻断肿瘤细胞与血管内皮间的黏附作用，抑制转移灶形成，为抗肿瘤转移治疗提供潜在靶点。
4. **文献名称**: *"Structural Insights into CD62P-Ligand Interactions via Antibody Epitope Mapping"*
**作者**: Tanaka K, et al.
**摘要**: 通过表位定位分析揭示了抗CD62P抗体与P-选择素特定结构域的结合机制，为优化抗体药物设计提供了分子基础。
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**注**：以上为模拟示例，实际文献需通过PubMed或学术数据库检索。建议使用关键词“CD62P antibody”、“P-selectin blockade”或结合研究领域(如血栓、炎症、癌症)进一步筛选。
CD62P, also known as P-selectin, is a cell adhesion molecule belonging to the selectin family. It is primarily expressed on activated platelets and endothelial cells, where it mediates leukocyte rolling and adhesion during inflammatory responses or thrombotic events. Structurally, CD62P is a transmembrane glycoprotein composed of an N-terminal lectin domain, an epidermal growth factor (EGF)-like domain, multiple consensus repeat units, a transmembrane region, and a cytoplasmic tail. It is stored in intracellular granules (Weibel-Palade bodies in endothelial cells and α-granules in platelets) and rapidly translocates to the cell surface upon activation by stimuli like thrombin, histamine, or cytokines.
CD62P antibodies are critical tools for detecting and quantifying P-selectin expression, serving as biomarkers for platelet activation and endothelial dysfunction in conditions such as atherosclerosis, thrombosis, sepsis, and ischemia-reperfusion injury. These antibodies enable researchers to study CD62P's role in cell-cell interactions through techniques like flow cytometry, immunohistochemistry, and Western blotting. Therapeutic CD62P-targeting antibodies or inhibitors are also under investigation to mitigate pathological inflammation or thrombotic disorders by blocking leukocyte-platelet or leukocyte-endothelium interactions. Their development highlights CD62P's dual role as a mediator of both physiological hemostasis and pathological vascular inflammation.
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