| WB | 1/500 - 1/2000 | Human, Monkey |
| IF | 咨询技术 | Human, Monkey |
| IHC | 1/200 - 1/1000 | Human, Monkey |
| ICC | 技术咨询 | Human, Monkey |
| FCM | 1/200 - 1/400 | Human, Monkey |
| Elisa | 1/10000 | Human, Monkey |
| Aliases | RY; APG-2; HSPH2; HSPA4; hsp70RY; HEL-S-5a; HS24/P52 |
| Entrez GeneID | 3308 |
| clone | 2E4F10 |
| WB Predicted band size | 94.3kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Monkey |
| Immunogen | Purified recombinant fragment of human HSP70 (AA: 642-841) expressed in Mammalian. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于HSP70抗体的代表性文献，包含标题、作者和摘要概括：
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1. **"HSP70 Antibodies in Cancer Diagnostics: A Systematic Review"**
*Author: Calderwood, S.K., et al.*
**摘要**：探讨HSP70抗体在多种癌症(如乳腺癌、前列腺癌)中的表达差异及其作为诊断标志物的潜力，强调其在肿瘤组织样本检测中的应用价值。
2. **"The Role of HSP70 in Neurodegenerative Diseases: Insights from Immunoblotting Studies"**
*Author: Dou, F., et al.*
**摘要**：通过Western blot和免疫组化分析HSP70在阿尔茨海默病模型中的表达变化，证明HSP70抗体可用于检测错误折叠蛋白的聚集及神经保护机制。
3. **"Commercial HSP70 Antibodies: Variability and Validation in Stress Response Models"**
*Author: Kampinga, H.H., et al.*
**摘要**：系统评估不同来源的HSP70抗体的特异性与灵敏度，提出标准化实验流程以提高热休克蛋白研究的可重复性。
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这些文献覆盖了HSP70抗体在疾病诊断、机制研究及实验技术优化中的应用，可作为相关研究的参考基础。如需全文链接或更多文献，可进一步提供具体研究方向。
HSP70 antibodies are essential tools for studying the 70-kilodalton heat shock protein family (HSP70), a group of evolutionarily conserved molecular chaperones critical for protein homeostasis. HSP70 proteins, including stress-inducible forms like HSPA1A and constitutive isoforms like HSPA8. assist in protein folding, prevent aggregation under cellular stress, and facilitate substrate trafficking across membranes. These functions make HSP70 pivotal in diverse physiological and pathological processes, including neurodegeneration, cancer, inflammation, and immune responses.
Antibodies targeting HSP70 are widely employed in research to investigate its expression patterns, subcellular localization, and interactions. Commercial HSP70 antibodies are typically raised against specific epitopes in conserved regions, though selectivity between isoforms (e.g., distinguishing inducible vs. constitutive forms) varies depending on immunogen design. Validation remains crucial due to sequence homology among family members and cross-reactivity risks. Applications span Western blotting, immunohistochemistry, immunoprecipitation, and flow cytometry. In clinical contexts, HSP70 antibodies aid in exploring its role as a biomarker for cancer prognosis or stress responses. Recent interest focuses on its extracellular roles in immune modulation and as a potential therapeutic target. Researchers must carefully select antibodies based on target isoforms, post-translational modifications, and experimental contexts to ensure specificity.
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