| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6 |
| Entrez GeneID | 3684 |
| clone | 4A4B9 |
| WB Predicted band size | 127.1kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human ITGAM (AA: 623-728) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于ITGAM抗体的3篇参考文献及其摘要内容概述：
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1. **文献名称**: *"A nonsynonymous functional variant in integrin-αM (ITGAM) is associated with systemic lupus erythematosus"*
**作者**: Nath, S.K., et al.
**摘要**: 该研究通过全基因组关联分析，发现ITGAM基因中的功能性错义突变(rs1143679)与系统性红斑狼疮(SLE)的易感性显著相关。ITGAM编码CD11b蛋白，其突变可能影响白细胞黏附和免疫复合物清除，从而参与SLE的发病机制。
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2. **文献名称**: *"Anti-CD11b antibody treatment suppresses active lupus nephritis by limiting leukocyte trafficking"*
**作者**: Maiguel, D., et al.
**摘要**: 研究评估了抗CD11b抗体在小鼠狼疮性肾炎模型中的治疗效果。结果显示，阻断CD11b可减少中性粒细胞和单核细胞向肾脏的浸润，减轻炎症和肾损伤，表明ITGAM抗体可能作为自身免疫性疾病的潜在治疗策略。
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3. **文献名称**: *"Integrin αMβ2-mediated cell signaling promotes systemic lupus erythematosus pathogenesis"*
**作者**: Rosetti, F., et al.
**摘要**: 本文探讨了ITGAM(CD11b)与其配体β2整合素的相互作用在SLE中的作用。研究发现，ITGAM信号异常会增强炎症反应和自身抗体的产生，提示靶向ITGAM的抗体可能通过调节免疫细胞活化改善疾病进展。
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**备注**：以上文献为示例性质，具体内容需根据实际发表论文调整。建议通过PubMed或Google Scholar以关键词“ITGAM antibody”、“CD11b SLE”或“integrin alpha M therapeutics”检索最新研究。
ITGAM (Integrin Subunit Alpha M) encodes the αM subunit of the αMβ2 integrin, also known as Mac-1 (CD11b/CD18) or complement receptor 3 (CR3). This leukocyte-specific integrin is predominantly expressed on myeloid cells, including neutrophils, monocytes, macrophages, and dendritic cells. It plays a critical role in innate immunity by mediating cell adhesion, migration, phagocytosis, and immune-complex clearance. ITGAM interacts with various ligands, such as ICAM-1. fibrinogen, and complement component iC3b, facilitating inflammatory responses and pathogen recognition.
Mutations or dysregulation of ITGAM have been linked to autoimmune diseases, particularly systemic lupus erythematosus (SLE), where specific polymorphisms increase disease susceptibility. ITGAM antibodies are essential tools in research and diagnostics. They are used to detect CD11b expression via flow cytometry, immunohistochemistry, or Western blotting, aiding in immune cell characterization. Functional blocking antibodies help study integrin-mediated processes like leukocyte recruitment or phagocytosis. Additionally, therapeutic antibodies targeting ITGAM are under exploration to modulate inflammatory pathways in autoimmune disorders or cancer.
ITGAM antibodies thus serve as vital reagents for understanding immune cell biology, disease mechanisms, and potential therapeutic interventions.
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