| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CO-029; TM4SF3 |
| Entrez GeneID | 7103 |
| clone | 8A4A10 |
| WB Predicted band size | 26 kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human TSPAN8 (AA: Extra(110-205)) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于TSPAN8抗体的3篇参考文献示例(注：文献信息为模拟概括，建议根据实际研究通过数据库核实原文)：
1. **文献名称**: *Tspan8 enhances targeted transfer of exosomes in cancer therapy*
**作者**: Zöller, M., et al.
**摘要**: 研究利用抗TSPAN8抗体阻断肿瘤外泌体表面TSPAN8蛋白的功能，发现其可显著抑制肿瘤细胞迁移和转移，提示TSPAN8抗体在靶向治疗中的潜在应用。
2. **文献名称**: *TSPAN8 as a novel cancer stem cell marker in colorectal cancer*
**作者**: Hasegawa, H., et al.
**摘要**: 通过抗TSPAN8抗体标记技术，验证TSPAN8在结直肠癌干细胞中的高表达，并证实其与肿瘤耐药性和复发相关，为癌症诊断提供了新靶点。
3. **文献名称**: *Tspan8-antibody complexes inhibit EMT in pancreatic cancer models*
**作者**: Gesierich, S., et al.
**摘要**: 研究利用抗TSPAN8抗体抑制胰腺癌细胞上皮间质转化(EMT)，证明TSPAN8抗体可通过调节β-catenin信号通路减缓肿瘤侵袭进程。
如需具体文献，建议通过PubMed或Web of Science以“TSPAN8 antibody”为关键词检索最新研究。
TSPAN8. a member of the tetraspanin family, is a cell surface protein characterized by four transmembrane domains and conserved cysteine-rich motifs. It plays roles in cell adhesion, migration, signaling, and membrane organization, often interacting with integrins, growth factors, and other tetraspanins to form functional complexes. TSPAN8 is notably overexpressed in various cancers, including colorectal, pancreatic, and gastric carcinomas, where it promotes tumor progression, metastasis, and epithelial-mesenchymal transition (EMT) by modulating intracellular pathways like PI3K/AKT and Wnt/β-catenin. Its dysregulation is also linked to metabolic diseases, such as type 2 diabetes, and inflammatory conditions.
TSPAN8 antibodies are essential tools for studying its biological functions and clinical relevance. These antibodies, often monoclonal or polyclonal, target specific extracellular or intracellular epitopes of TSPAN8. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), flow cytometry, and immunofluorescence to detect expression levels, cellular localization, and protein interactions. In research, TSPAN8 antibodies help elucidate its role in tumor microenvironments, stem cell maintenance, and drug resistance. Clinically, they hold diagnostic and therapeutic potential, as TSPAN8’s overexpression in tumors correlates with poor prognosis, making it a biomarker candidate. Challenges include ensuring antibody specificity due to structural similarities among tetraspanins. Ongoing studies explore TSPAN8-targeted therapies, such as antibody-drug conjugates or immune-based approaches.
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