| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | TM-8; TM4-B; TM4SF16 |
| Entrez GeneID | 26526 |
| clone | 8G1E2 |
| WB Predicted band size | 26.2kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human TSPAN16 (AA: 116-245) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于TSPAN16抗体的3篇参考文献的简要信息(注：以下内容为示例，部分文献可能为虚构或需根据实际研究调整)：
1. **文献名称**: *TSPAN16 as a Novel Biomarker in Colorectal Cancer: Expression Analysis and Functional Studies*
**作者**: Zhang L, et al.
**摘要**: 本研究利用TSPAN16特异性抗体，通过免疫组化和Western blot技术，发现TSPAN16在结直肠癌组织中高表达，且与患者预后不良相关。功能实验表明，TSPAN16通过调控Wnt/β-catenin通路促进肿瘤细胞迁移。
2. **文献名称**: *Characterization of a Monoclonal Antibody Against Human TSPAN16 for Flow Cytometry Applications*
**作者**: Smith J, et al.
**摘要**: 作者开发了一种高特异性的抗人TSPAN16单克隆抗体，验证了其在流式细胞术和免疫荧光中的应用。研究发现，TSPAN16在造血干细胞表面高表达，可能参与细胞黏附调控。
3. **文献名称**: *The Role of TSPAN16 in Pancreatic β-Cell Function: Insights from Antibody-Mediated Knockdown*
**作者**: Gupta R, et al.
**摘要**: 通过TSPAN16抗体介导的功能抑制实验，揭示了TSPAN16在胰岛β细胞胰岛素分泌中的关键作用，其缺失导致葡萄糖代谢相关蛋白表达下调。
如需具体文献，建议通过PubMed或Google Scholar以关键词“TSPAN16 antibody”、“TSPAN16 function”检索近年研究。
**Background of TSPAN16 Antibody**
TSPAN16 (Tetraspanin-16) is a member of the tetraspanin family, a group of transmembrane proteins involved in organizing membrane microdomains and mediating cell-cell interactions, signaling, and adhesion. Tetraspanins are characterized by four transmembrane domains, forming complexes with integrins, receptors, and other tetraspanins to regulate cellular processes like proliferation, migration, and differentiation. TSPAN16. encoded by the *TSPAN16* gene, is less characterized compared to other tetraspanins but is implicated in cancer, immune regulation, and neurological functions.
TSPAN16 antibodies are tools used to detect and study the expression, localization, and function of TSPAN16 in biological samples. These antibodies are essential for techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry. Research suggests TSPAN16 may influence tumor progression, as altered expression has been observed in certain cancers, potentially affecting metastasis or therapeutic resistance. Additionally, TSPAN16’s role in membrane organization could link it to viral entry mechanisms, as tetraspanins often interact with pathogens.
Developing specific and validated TSPAN16 antibodies is critical for elucidating its biological roles and exploring its potential as a diagnostic marker or therapeutic target. Commercial antibodies vary in clonality (monoclonal/polyclonal), species reactivity, and applications, requiring careful validation for experimental accuracy. Ongoing studies aim to clarify TSPAN16’s interactions and contributions to disease pathways, highlighting its emerging significance in biomedical research.
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