| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/50 - 1/200 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | GM130 |
| Entrez GeneID | 2801 |
| clone | 2D3D12 |
| WB Predicted band size | 113kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human GOLGA2 (AA: 1-205) expressed in HEK293-6e cells supernatant. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
+ +
以下为3篇与GOLGA2抗体相关的研究文献示例：
1. **文献名称**：Golgin-84 is required for Golgi structure formation during mitosis
**作者**：Diao A, Rahman D, Pappin DJ, Lucocq J, Lowe M
**摘要**：该研究利用GOLGA2(GM130)抗体探究高尔基体基质蛋白(包括GM130和golgin-84)在细胞分裂过程中维持高尔基体碎片化结构的作用，发现这些蛋白对高尔基体重新组装至关重要。
2. **文献名称**：Expression of Golgi protein GOLGA2 in colorectal cancer progression and its clinical significance
**作者**：Lin Y, Xu J, Lu H, et al.
**摘要**：通过免疫组化分析GOLGA2在结直肠癌组织中的表达，发现其高表达与肿瘤转移和不良预后相关，提示GOLGA2可能作为癌症生物标志物。
3. **文献名称**：Herpes simplex virus 1 cytoplasmic envelopment requires functional Golgi recruitment by its membrane protein US10
**作者**：Metrick CM, Koenigsberg AL, Heldwein EE
**摘要**：研究利用GOLGA2抗体标记高尔基体，发现疱疹病毒US10蛋白通过干扰高尔基体结构促进病毒包膜形成，揭示病毒劫持宿主细胞器的机制。
注：以上文献为示例，实际引用时建议通过PubMed等数据库核对最新研究。GOLGA2抗体常用于研究高尔基体结构、癌症及病毒感染机制。
GOLGA2 antibodies are primarily associated with research on the Golgi apparatus and autoimmune disorders. GOLGA2. also known as Golgin A2 or GM130. is a peripheral membrane protein located on the Golgi stack. It plays a critical role in maintaining Golgi structure, vesicle trafficking, and glycosylation processes. Antibodies targeting GOLGA2 are widely used as markers in immunofluorescence and immunoblotting to visualize the Golgi complex in cellular studies.
In clinical contexts, GOLGA2 autoantibodies have been identified in certain autoimmune conditions. Notably, they are detected in a subset of patients with paraneoplastic syndromes, particularly those with cancer-associated retinopathy (CAR) or melanoma-associated retinopathy (MAR). These autoantibodies may arise due to molecular mimicry between tumor antigens and retinal proteins, triggering immune cross-reactivity. Additionally, GOLGA2 antibodies have been reported in rare cases of autoimmune hepatitis and connective tissue disorders, though their pathogenicity remains unclear.
Research also links GOLGA2 dysregulation to cancer progression. Overexpression of GOLGA2 is observed in malignancies like hepatocellular carcinoma and colorectal cancer, potentially influencing cell proliferation and metastasis. However, most studies focus on its role as an autoantigen or structural protein rather than a therapeutic target. Continued investigation aims to clarify its diagnostic utility and mechanistic contributions to disease pathways.
×
