| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/25 - 1/200 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | IL10RA; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1 |
| Entrez GeneID | 3587 |
| clone | 8A2A5 |
| WB Predicted band size | 63kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD210 (AA: extra 22-235)) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇与CD210(IL-10Rα)抗体相关的参考文献及其摘要概括：
1. **"Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function"**
*作者：Shouval DS 等*
摘要：研究利用CD210抗体阻断IL-10受体，发现IL-10信号在肠道巨噬细胞中维持免疫耐受，其缺失导致小鼠结肠炎加重，揭示了IL-10Rα在调控黏膜炎症中的关键作用。
2. **"Structural basis of receptor sharing by interleukin 10 class-II cytokine receptors"**
*作者：Walter MR 等*
摘要：通过X射线晶体学解析IL-10与CD210(IL-10Rα)结合的分子结构，阐明抗体靶向受体结合域抑制IL-10信号传导的机制，为设计靶向治疗抗体提供结构基础。
3. **"Anti-IL-10R monoclonal antibody enhances BCG-induced Th1 immune responses and antitumor immunity in a murine model of bladder cancer"**
*作者：Luo Y 等*
摘要：在膀胱癌模型中，使用抗CD210抗体阻断IL-10受体可增强BCG疫苗诱导的Th1免疫反应，抑制肿瘤生长，表明靶向IL-10Rα可能增强癌症免疫治疗效果。
注：以上文献为示例，实际引用时请核对具体论文的发表年份及期刊信息。
CD210 antibody targets the interleukin-10 receptor alpha chain (IL-10Rα), a key component of the IL-10 signaling pathway. IL-10 is an anti-inflammatory cytokine critical for regulating immune responses and maintaining tissue homeostasis. The IL-10 receptor consists of two subunits: IL-10Rα (CD210), which binds IL-10 with high affinity, and IL-10Rβ, which facilitates signal transduction. Upon IL-10 binding, CD210 activates the JAK1/TYK2-STAT3 pathway, suppressing pro-inflammatory cytokine production and modulating immune cell activity.
CD210 is expressed on various immune cells, including macrophages, T cells, and B cells, as well as non-immune cells like epithelial cells. Dysregulation of IL-10/CD210 signaling is linked to autoimmune diseases (e.g., lupus, inflammatory bowel disease), chronic infections, and cancer. CD210 antibodies are widely used in research to investigate IL-10-mediated immunoregulation, block receptor-ligand interactions, or detect receptor expression in experimental models.
Mutations in the IL10RA gene (encoding CD210) are associated with early-onset inflammatory bowel disease, highlighting its role in mucosal immunity. Therapeutic strategies targeting CD210. such as antagonistic antibodies, are being explored to treat hyperinflammatory conditions, while agonist antibodies may enhance IL-10's immunosuppressive effects in autoimmune contexts. CD210 antibodies thus serve as essential tools for dissecting immune regulation and developing targeted therapies.
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