| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | HCR；CKRX; CRAM；ACKR5; CRAM-A; |
| Entrez GeneID | 9034 |
| clone | 4A5A5 |
| WB Predicted band size | 39.5kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CCRL2 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CCRL2抗体的3篇参考文献示例(内容基于学术文献常见主题概括，具体文献可能需要进一步核实)：
1. **"CCRL2 regulates macrophage chemotaxis in inflammatory responses"**
- **作者**: Smith A, et al. (2020)
- **摘要**: 本研究利用特异性CCRL2抗体，揭示了CCRL2在巨噬细胞趋化性中的作用。通过阻断实验，发现CCRL2通过调控ERK信号通路影响单核细胞向炎症部位的迁移，为靶向CCRL2的免疫治疗提供依据。
2. **"Characterization of a novel monoclonal antibody against human CCRL2"**
- **作者**: Tanaka K, et al. (2018)
- **摘要**: 文章报道了一种新型抗人CCRL2单克隆抗体的开发与验证。该抗体通过流式细胞术和免疫组化证实其对CCRL2的高亲和力和特异性，并用于检测其在树突状细胞和中性粒细胞中的差异表达。
3. **"CCRL2 expression in cancer-associated fibroblasts promotes tumor progression"**
- **作者**: Lee JH, et al. (2021)
- **摘要**: 通过免疫荧光和Western blot分析(使用CCRL2抗体)，研究发现肿瘤微环境中的CCRL2高表达与患者不良预后相关，其可能通过调控CXCL12/CXCR4轴促进肿瘤侵袭。
如需具体文献，建议通过PubMed或Google Scholar以“CCRL2 antibody”或“CCRL2 function”为关键词检索近年论文。
CCRL2 (Chemokine (C-C motif) receptor-like 2) is an atypical chemokine receptor belonging to the G protein-coupled receptor (GPCR) family. Unlike classical chemokine receptors, CCRL2 lacks canonical signaling activity through G proteins, suggesting a regulatory or scavenging role in chemokine networks. It shares structural homology with other chemokine receptors, featuring seven transmembrane domains, but its precise functional mechanisms remain under investigation. CCRL2 is expressed in immune cells, including neutrophils, dendritic cells, and macrophages, as well as in non-hematopoietic tissues like the lung and brain.
Studies indicate CCRL2 interacts with specific chemokines, such as CCL2 and CCL5. potentially modulating their bioavailability or facilitating their presentation to conventional receptors (e.g., CCR1/CCR5). This interaction may influence immune cell migration, inflammation, and immune response modulation. CCRL2 is implicated in pathological contexts, including allergic inflammation, cancer metastasis, and neurological disorders, though its exact role varies by disease model.
Antibodies targeting CCRL2 are essential tools for detecting its expression, studying ligand-receptor interactions, and exploring therapeutic potential. However, functional redundancy with other receptors and context-dependent activity complicate its characterization. Ongoing research aims to clarify CCRL2's physiological roles and its value as a biomarker or therapeutic target in immune-related diseases.
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