Mouse Monoclonal MUC12 Antibody

The MUC12 antibody targets the MUC12 glycoprotein, a member of the mucin family, which are high-molecular-weight glycoproteins critical for epithelial cell protection, lubrication, and cell signaling. MUC12 is encoded by the *MUC12* gene, located on chromosome 7q22. and is characterized by its tandem repeat-rich extracellular domain, a hallmark of secreted or membrane-bound mucins. It is predominantly expressed in epithelial tissues, particularly in the gastrointestinal tract, where it contributes to mucosal barrier function and pathogen defense. Dysregulation of MUC12 has been implicated in various pathologies, including cancer. Overexpression or aberrant glycosylation of MUC12 is observed in colorectal, gastric, and pancreatic cancers, where it may promote tumor progression by enhancing cell adhesion, metastasis, and immune evasion. MUC12 antibodies are valuable tools for studying its expression patterns, post-translational modifications, and functional roles in both normal and diseased states. They are used in immunohistochemistry, Western blotting, and ELISA to assess MUC12 as a potential diagnostic or prognostic biomarker. Additionally, therapeutic applications are being explored, such as antibody-drug conjugates or immune checkpoint inhibitors targeting MUC12-overexpressing malignancies. Research remains ongoing to elucidate its precise mechanisms in carcinogenesis and its utility in clinical settings.