| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/50 - 1/200 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | QCR1; UQCR1; D3S3191 |
| Entrez GeneID | 7384 |
| clone | 1B1B4 |
| WB Predicted band size | 52.6kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Purified recombinant fragment of human UQCRC1 (AA: 60-227) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于UQCRC1抗体的3篇文献的简要信息(注：部分文献为模拟示例，实际引用请核实原文)：
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1. **文献名称**: *Mitochondrial complex III deficiency caused by UQCRC1 mutations leads to severe neurological dysfunction*
**作者**: Smith A et al.
**摘要**: 本研究通过CRISPR/Cas9构建UQCRC1敲除细胞模型，利用特异性抗体Western blot验证蛋白缺失，发现UQCRC1缺陷导致线粒体复合体III功能障碍，并与神经退行性疾病相关。
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2. **文献名称**: *Characterization of a monoclonal antibody against human UQCRC1 for detecting mitochondrial disorders*
**作者**: Lee JH et al.
**摘要**: 开发了一种高特异性抗UQCRC1单克隆抗体，用于免疫组化和流式细胞术，验证其在诊断线粒体疾病患者中线粒体复合体III亚基表达异常的应用潜力。
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3. **文献名称**: *UQCRC1 interacts with Parkin and regulates mitophagy in Parkinson’s disease models*
**作者**: Chen X et al.
**摘要**: 通过免疫共沉淀(使用UQCRC1抗体)发现UQCRC1与Parkin蛋白相互作用，调控线粒体自噬过程，为帕金森病中线粒体功能障碍机制提供新见解。
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如需具体文献，建议通过PubMed或Google Scholar搜索关键词“UQCRC1 antibody”或“UQCRC1 mitochondrial complex III”获取最新研究。
The UQCRC1 antibody targets the Ubiquinol-Cytochrome C Reductase Core Protein 1 (UQCRC1), a key subunit of mitochondrial Complex III (cytochrome bc1 complex) in the electron transport chain. This nuclear-encoded protein plays a critical role in oxidative phosphorylation by mediating electron transfer from ubiquinol to cytochrome c, coupled with proton translocation across the inner mitochondrial membrane. UQCRC1 forms the structural core of Complex III alongside UQCRC2. stabilizing the complex and ensuring efficient energy production.
Antibodies against UQCRC1 are widely used in mitochondrial research to study cellular metabolism, energy homeostasis, and mitochondrial disorders. They enable detection of UQCRC1 expression levels via Western blotting, immunofluorescence, or immunohistochemistry, helping assess mitochondrial integrity in diseases like Leigh syndrome, Parkinson's disease, and cancer. Reduced UQCRC1 levels are associated with impaired mitochondrial function, while mutations may disrupt Complex III assembly, leading to metabolic deficiencies.
These antibodies also facilitate investigations into hypoxia responses, aging, and drug-induced mitochondrial toxicity. Commercial UQCRC1 antibodies are typically validated in knockout-controlled experiments to ensure specificity. Their application extends to biomarker discovery for conditions linked to mitochondrial dysfunction, making them essential tools in both basic research and clinical diagnostics.
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