Mouse Monoclonal GPR56 Antibody

GPR56 (ADGRG1), a member of the adhesion G protein-coupled receptor (aGPCR) family, is a transmembrane protein involved in cell adhesion, signaling, and tissue development. It plays critical roles in neurodevelopment, myelination, and cancer progression, with mutations linked to cortical malformations and other disorders. GPR56 antibodies are essential tools for studying its expression, localization, and functional mechanisms. These antibodies target specific extracellular or intracellular epitopes, enabling applications like Western blotting, immunohistochemistry, and flow cytometry. Research using GPR56 antibodies has revealed its tissue-specific expression in the brain, immune cells, and tumors, highlighting its dual roles in developmental processes and disease pathways. For example, GPR56 is implicated in suppressing tumor metastasis in melanoma and modulating synaptic plasticity. Challenges in antibody development include addressing post-translational modifications and splice variants, which may affect detection specificity. Recent studies also explore GPR56's interaction with extracellular matrix components like collagen III, shedding light on its mechanosensory functions. Validated GPR56 antibodies are crucial for advancing therapeutic research, particularly in neurological disorders and cancer immunotherapy.