Mouse Monoclonal C5AR2 Antibody

The C5a receptor 2 (C5AR2. also known as GPR77 or C5L2) is a G protein-coupled receptor (GPCR) that binds complement component C5a, a potent inflammatory mediator generated during complement system activation. Initially considered a "decoy receptor" due to its inability to trigger classical G protein signaling, C5AR2 has emerged as a key modulator of immune and inflammatory responses. Unlike its homolog C5aR1 (C5AR1), which activates pro-inflammatory pathways via G protein coupling, C5AR2 signals through β-arrestin-dependent mechanisms, regulating cellular processes like chemotaxis, cytokine release, and immune cell activation. C5AR2 antibodies are critical tools for studying its complex roles in diseases such as sepsis, autoimmune disorders, cancer, and metabolic conditions. These antibodies enable detection of C5AR2 expression in tissues, block ligand-receptor interactions, or modulate downstream signaling in experimental models. Recent studies highlight its dual role in inflammation—both enhancing and suppressing immune responses depending on context—making C5AR2 a potential therapeutic target. Challenges remain in fully elucidating its signaling crosstalk with C5aR1 and non-canonical ligands. Research using C5AR2-specific antibodies continues to clarify its pathophysiological contributions, aiding drug discovery efforts aimed at fine-tuning complement-mediated immunity.