Mouse Monoclonal TLR10 Antibody

Toll-like receptor 10 (TLR10) is a member of the Toll-like receptor family, which plays a critical role in innate immune responses by recognizing pathogen-associated molecular patterns (PAMPs). Unlike other TLRs with well-defined ligands, TLR10's specific agonists and functional mechanisms remain less understood, partly due to its unique structural and signaling properties. It is primarily expressed in immune cells, including B cells, monocytes, and dendritic cells, and forms heterodimers with TLR1 or TLR2 to modulate inflammatory signaling pathways. TLR10 antibodies are essential tools for studying its expression, localization, and functional interactions. Research suggests TLR10 may have dual roles—promoting or suppressing inflammation—depending on cellular context and disease states, such as autoimmune disorders, infections, and cancers. Antibodies targeting TLR10 enable investigations into its regulatory mechanisms, ligand identification, and therapeutic potential. However, challenges persist in distinguishing TLR10-specific signals from cross-reactivity with other TLRs in dimeric complexes. Recent studies using TLR10 knockout models and monoclonal antibodies highlight its emerging role in immune homeostasis, making it a promising target for immunotherapy and biomarker development.