| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | ITGAV; MSK8; VNRA; VTNR |
| Entrez GeneID | 3685 |
| clone | 3H1A5 |
| WB Predicted band size | 116kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD51 (AA: extra 31-189) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD51抗体的参考文献示例(内容为模拟虚构，仅作格式参考)：
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1. **文献名称**：*CD51/Integrin αV as a Therapeutic Target in Tumor Angiogenesis*
**作者**：Zhang, Y. et al.
**摘要**：研究通过CD51抗体阻断整合素αV亚基的功能，显著抑制了肿瘤血管生成和转移，表明其作为抗肿瘤治疗的潜在靶点。
2. **文献名称**：*CD51 Antibody Modulates Immune Response in Autoimmune Encephalomyelitis*
**作者**：Smith, J.R. & Lee, M.
**摘要**：实验证明，CD51抗体通过调控T细胞黏附和迁移，减轻了小鼠多发性硬化模型的中枢神经系统炎症损伤。
3. **文献名称**：*CD51-Mediated Adhesion in Fibrosis Progression*
**作者**：Wang, L. et al.
**摘要**：利用CD51抗体抑制成纤维细胞整合素αV活性，可减少胶原沉积，为抗纤维化治疗提供新策略。
4. **文献名称**：*CD51 Expression in Cancer Stem Cells and Therapeutic Implications*
**作者**：Garcia, P. et al.
**摘要**：CD51抗体靶向肿瘤干细胞表面标记物αV整合素，增强化疗敏感性并降低肿瘤复发风险。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词“CD51 antibody”“Integrin αV therapeutic”等，并筛选近年高引论文。
The CD51 antibody targets the CD51 antigen, also known as integrin αV, a subunit of the heterodimeric integrin family receptors. Integrins are transmembrane proteins mediating cell-cell and cell-extracellular matrix (ECM) interactions, crucial for adhesion, migration, signaling, and tissue homeostasis. The αV subunit pairs with various β subunits (e.g., β1. β3. β5. β6. β8) to form distinct integrins (e.g., αVβ3. αVβ5), each recognizing specific ECM ligands like vitronectin, fibronectin, and osteopontin via RGD motifs. CD51 is broadly expressed in endothelial cells, osteoclasts, platelets, and immune cells, and is upregulated in pathological states such as cancer, angiogenesis, and inflammation.
CD51 antibodies are vital tools in research and therapeutics. They block integrin-mediated pathways, offering potential in anti-angiogenic cancer therapies, as αV-containing integrins promote tumor growth and metastasis. In diagnostics, CD51 antibodies help identify αV-expressing cells in tissues, aiding cancer prognosis. They also explore roles in fibrosis, wound healing, and immune regulation. However, challenges remain in specificity due to αV's multiple β pairings, necessitating precise antibody design. Current studies focus on optimizing CD51-targeted agents for conditions like age-related macular degeneration and fibrotic diseases, highlighting its translational significance.
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