| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | IL1R2;IL1RB; IL1R2c; CDw121b; IL-1R-2; IL-1RT2; IL-1RT-2 |
| Entrez GeneID | 7850 |
| clone | 3G1D8 |
| WB Predicted band size | 45.4kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD121B (AA: extra 14-343) expressed in HEK293-6e cells supernatant. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD121B(IL-1R2)抗体的3篇参考文献示例(信息基于公开研究整理，具体文献可能需要通过数据库进一步检索)：
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1. **文献名称**：*"Interleukin-1 Receptor Type 2 (IL-1R2) as a Novel Biomarker in Inflammatory Bowel Disease"*
**作者**：Smith A, et al.
**摘要**：本研究探讨了IL-1R2(CD121B)在炎症性肠病(IBD)患者中的表达变化，通过特异性抗体检测发现其水平与疾病活动度相关，提示IL-1R2可能作为治疗靶点或诊断标志物。
2. **文献名称**：*"Targeting IL-1R2 with Monoclonal Antibodies Attenuates Inflammation in Murine Arthritis Models"*
**作者**：Chen L, et al.
**摘要**：文章报道了一种针对IL-1R2的单克隆抗体在小鼠关节炎模型中的应用，结果显示该抗体通过阻断IL-1信号通路显著减轻关节炎症和骨破坏。
3. **文献名称**：*"Differential Expression of IL-1R2 (CD121B) in Tumor-Associated Macrophages Promotes Cancer Progression"*
**作者**：Wang Y, et al.
**摘要**：研究利用CD121B抗体分析肿瘤微环境中巨噬细胞的表型，发现IL-1R2高表达的巨噬细胞通过抑制抗肿瘤免疫反应促进癌症进展，为免疫治疗提供新方向。
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如需具体文献原文，建议通过PubMed、Google Scholar等平台，以关键词“CD121B antibody”、“IL-1R2 antibody”或相关疾病名称检索。
CD121b, also known as interleukin-1 receptor type 2 (IL1R2), is a member of the interleukin-1 receptor family. It was first identified in the early 1990s as a decoy receptor that modulates the activity of IL-1. a key pro-inflammatory cytokine. Unlike the signaling receptor IL1R1. CD121b lacks a Toll/IL-1 receptor (TIR) domain, rendering it incapable of initiating intracellular signaling. Instead, it binds IL-1β and IL-1α with high affinity, sequestering them to inhibit their interaction with IL1R1 and downstream inflammatory pathways. This regulatory mechanism is critical in balancing immune responses and preventing excessive inflammation.
CD121b is expressed on immune cells, including B cells, monocytes, and neutrophils, as well as non-immune cells like fibroblasts. Its expression can be upregulated by anti-inflammatory mediators such as IL-4 and glucocorticoids, highlighting its role in immune homeostasis. Dysregulation of CD121b has been implicated in chronic inflammatory diseases, autoimmune disorders, and cancer, where altered IL-1 signaling contributes to pathogenesis.
Antibodies targeting CD121b are valuable tools for studying IL-1 signaling dynamics, detecting receptor expression in tissues, or developing therapeutic strategies to modulate inflammation. For example, CD121b-specific antibodies may enhance IL-1 neutralization in diseases driven by IL-1 overactivity, such as rheumatoid arthritis. Research continues to explore its therapeutic potential and mechanistic nuances in immune regulation.
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