Mouse Monoclonal CD360 Antibody

The CD360 antibody targets CD360. a cell surface protein belonging to the scavenger receptor cysteine-rich (SRCR) superfamily. Initially identified as a B-cell-associated antigen, CD360 (also known as HAIR, TOSO, or Fas apoptotic inhibitory molecule 3) plays roles in immune regulation and apoptosis resistance. It interacts with Fas (CD95), inhibiting Fas-mediated apoptosis by blocking caspase-8 activation, which may contribute to autoimmune disorders or cancer immune evasion. CD360 is expressed on B cells, subsets of T cells, and certain myeloid cells. Its dual role in apoptosis modulation and immune cell signaling has drawn interest in therapeutic development. Antibodies against CD360 are used experimentally to study its function in diseases like chronic lymphocytic leukemia (CLL) and autoimmune conditions. Recent research explores CD360's involvement in regulating B-cell receptor signaling and cytokine production. However, its precise physiological ligands and signaling pathways remain partially unclear. CD360 antibodies serve as tools to dissect these mechanisms and evaluate therapeutic potential in targeting apoptosis-resistant malignancies or hyperactive immune responses.