| WB | 1/500 - 1/2000 | Human, Mouse, Monkey |
| IF | 咨询技术 | Human, Mouse, Monkey |
| IHC | 1/200 - 1/1000 | Human, Mouse, Monkey |
| ICC | 1/200 - 1/1000 | Human, Mouse, Monkey |
| FCM | 1/200 - 1/400 | Human, Mouse, Monkey |
| Elisa | 1/10000 | Human, Mouse, Monkey |
| Aliases | R4; T6; CD1; FCB6; HTA1 |
| Entrez GeneID | 909 |
| clone | 5B9C3 |
| WB Predicted band size | 37kDa |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Monkey |
| Immunogen | Purified recombinant fragment of human CD1A (AA: 17-116) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于CD1A抗体的参考文献及其核心内容概述：
1. **文献名称**: "CD1a immunohistochemistry in the differential diagnosis of Langerhans cell histiocytosis"
**作者**: Lau et al.
**摘要**: 该研究证实CD1A抗体在区分朗格汉斯细胞组织细胞增生症(LCH)与其他组织细胞增生性疾病中的关键作用，通过免疫组化显示CD1A特异性标记LCH细胞，为临床诊断提供可靠依据。
2. **文献名称**: "CD1a expression in dendritic cell subsets of the tumor microenvironment"
**作者**: Rodriguez-Pinto et al.
**摘要**: 探讨CD1A阳性树突状细胞在肿瘤微环境中的分布及功能，发现其通过脂质抗原呈递激活T细胞，提示CD1A抗体可用于评估肿瘤免疫治疗中的免疫细胞浸润状态。
3. **文献名称**: "Utility of CD1a staining in the diagnosis of cutaneous T-cell lymphoma"
**作者**: Wang et al.
**摘要**: 比较CD1A与其他标志物(如Langerin)在皮肤T细胞淋巴瘤诊断中的敏感性，指出CD1A抗体对早期病变中异常树突状细胞的识别具有辅助诊断价值，但需结合临床与其他标记物联用。
*注：上述文献为示例性质，具体内容建议通过PubMed/Google Scholar检索近年发表的实际研究。*
CD1a antibodies are essential tools in immunology research, targeting the CD1a glycoprotein, a member of the CD1 family of antigen-presenting molecules. CD1 proteins are structurally homologous to MHC class I molecules but specialize in presenting lipid antigens to T cells, bridging innate and adaptive immunity. CD1a, encoded by the *CD1A* gene, is predominantly expressed on dendritic cells, Langerhans cells, and cortical thymocytes. Its expression pattern underscores its role in skin immunity and thymic T-cell selection.
CD1a-restricted T cells recognize lipid antigens derived from pathogens (e.g., mycobacterial lipids) or self-tissues, contributing to antimicrobial defense and immune surveillance. CD1a antibodies are widely used to identify Langerhans cells in tissues, aiding the diagnosis of Langerhans cell histiocytosis and studying dendritic cell biology. They also help explore CD1a's involvement in inflammatory skin disorders (e.g., psoriasis) and cancers (e.g., T-cell lymphomas), where aberrant CD1a expression may influence tumor immunity.
Recent studies highlight CD1a's interaction with endogenous lipids, such as sphingolipids, expanding its role beyond infection to autoimmunity and metabolic regulation. Therapeutic applications, including CD1a-targeted vaccines or inhibitors, are under investigation. However, CD1a's limited species conservation (primates/humans) complicates translational models. Overall, CD1a antibodies remain pivotal in dissecting lipid antigen presentation mechanisms and developing immunotherapies.
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