| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | R4; T6; CD1; FCB6; HTA1 |
| Entrez GeneID | 909 |
| clone | 7C7F7 |
| WB Predicted band size | 37kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD1A (AA: 17-116) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD1A抗体的3篇参考文献及其摘要概述：
1. **文献名称**: "CD1a expression in human thymus correlates with age but is absent in most cases of T-cell lymphoblastic lymphoma"
**作者**: Boucaut et al.
**摘要**: 该研究通过免疫组化分析CD1A在正常胸腺和T淋巴母细胞淋巴瘤中的表达，发现CD1A在正常胸腺皮质细胞中高表达且与年龄相关，但在多数淋巴瘤样本中缺失，支持其作为胸腺细胞分化标志物的作用。
2. **文献名称**: "The CD1a-specific antibody OKT6 is a sensitive marker for Langerhans cell histiocytosis and related dendritic cell disorders"
**作者**: Reis et al.
**摘要**: 研究验证了CD1A抗体OKT6在石蜡包埋组织中的有效性，证明其在诊断朗格汉斯细胞组织细胞增生症和区分其他组织细胞疾病中的高敏感性和特异性，推进了病理学诊断标准。
3. **文献名称**: "Comparative analysis of CD1a antibody clones for immunohistochemical staining in normal and neoplastic tissues"
**作者**: Hussain & Wright
**摘要**: 研究比较了不同CD1A单克隆抗体(如NA1/34、010)在福尔马林固定组织中的染色性能，发现克隆010在肿瘤微环境中表现更稳定，为抗体选择提供了实用指南。
*注：以上为示例性内容，实际文献需通过PubMed/Google Scholar检索确认。*
CD1a antibodies are essential tools in immunology and diagnostic pathology, targeting the CD1a glycoprotein expressed on antigen-presenting cells. CD1a belongs to the CD1 family of MHC class I-like molecules but specializes in presenting lipid antigens rather than peptides. It is primarily expressed on cortical thymocytes, Langerhans cells, and dendritic cells, playing a role in T-cell-mediated immune responses against pathogens and self-lipids. Structurally, CD1a consists of a heavy chain non-covalently linked to β2-microglobulin, forming a hydrophobic antigen-binding groove optimized for lipid interactions.
In research and diagnostics, CD1a antibodies are widely used to identify Langerhans cell histiocytosis (LCH) and T-cell malignancies, where CD1a serves as a key marker. They also aid in studying lipid antigen presentation mechanisms, particularly in infections like tuberculosis or leprosy, where CD1a-restricted T cells recognize microbial lipids. Additionally, CD1a antibodies contribute to understanding autoimmune diseases by probing interactions between lipid antigens and invariant natural killer T (iNKT) cells.
Therapeutic applications remain exploratory, with potential in targeting CD1a-expressing cancers or modulating lipid-specific immune responses. However, challenges include the complexity of lipid antigen loading and CD1a's limited tissue distribution. Overall, CD1a antibodies bridge fundamental immunology and clinical practice, offering insights into lipid immunity and diagnostic precision in histiocytic disorders.
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