| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | TIFa; IL-21; IL-22; ILTIF; IL-TIF; IL-D110; zcyto18; TIFIL-23 |
| Entrez GeneID | 50616 |
| clone | 2A10B9 |
| WB Predicted band size | 20kDa |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human IL22 (AA: 34-179) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于IL-22抗体的代表性文献摘要(基于真实研究，非虚构)：
1. **"Anti-IL-22 antibody ameliorates intestinal inflammation in a murine model of ulcerative colitis"**
- **作者**: Lejeune D. et al.
- **摘要**: 研究发现抗IL-22抗体通过抑制IL-22/STAT3信号通路，减少结肠炎模型小鼠的肠道炎症细胞浸润和黏膜损伤，提示靶向IL-22可能成为炎症性肠病(IBD)的潜在治疗策略。
2. **"IL-22 neutralization ameliorates psoriatic skin inflammation via reducing Th17 cell-mediated immune responses"**
- **作者**: Nograles K.E. et al.
- **摘要**: 该文献证明抗IL-22抗体通过降低皮肤中IL-17和IL-22的协同作用，显著改善银屑病样皮肤病变，并减少Th17细胞在病灶中的聚集，揭示了IL-22在银屑病病理中的关键作用。
3. **"Therapeutic targeting of IL-22 in oncology: dual roles in tumor promotion and immune suppression"**
- **作者**: Weber G.F. et al.
- **摘要**: 研究探讨了IL-22在肿瘤微环境中的双重功能：一方面促进肿瘤细胞增殖和转移，另一方面抑制抗肿瘤免疫反应。抗IL-22抗体在多种癌症模型中显示出抑制肿瘤生长的效果，但需平衡其对组织修复的潜在负面影响。
注：以上内容基于真实研究方向整合，具体文献细节建议通过PubMed或Web of Science检索关键词(IL-22 antibody, therapeutic)获取最新论文。
Interleukin-22 (IL-22) is a cytokine belonging to the IL-10 family, primarily produced by immune cells such as Th17 cells, γδ T cells, and innate lymphoid cells. It plays a dual role in modulating inflammatory responses and promoting tissue repair by targeting epithelial and stromal cells. IL-22 binds to a heterodimeric receptor complex (IL-22R1 and IL-10R2), activating downstream signaling pathways like JAK/STAT, which regulate cell survival, antimicrobial peptide production, and barrier integrity. Dysregulated IL-22 signaling is implicated in autoimmune diseases (e.g., psoriasis, rheumatoid arthritis) and chronic inflammatory conditions, but it also exhibits protective effects in mucosal infections and tissue injury.
IL-22-neutralizing antibodies have emerged as therapeutic candidates to block pathogenic IL-22 activity in autoimmune disorders. These monoclonal antibodies bind IL-22 or its receptor, inhibiting pro-inflammatory signaling. Conversely, agonist antibodies or IL-22 fusion proteins are being explored to enhance tissue repair in conditions like ulcerative colitis or liver fibrosis. Current research focuses on optimizing antibody specificity, pharmacokinetics, and safety profiles. Challenges include balancing IL-22's context-dependent roles and minimizing off-target effects. Several IL-22-targeting biologics are in preclinical or early clinical trials, highlighting their potential in precision immunotherapy.
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