Mouse Monoclonal KRT9 Antibody

The keratin 9 (KRT9) antibody is a crucial tool in studying type I intermediate filament proteins, specifically keratin 9. which is predominantly expressed in the suprabasal layers of palmoplantar epidermis. KRT9 plays a structural role in maintaining epidermal integrity and resilience, particularly in high-friction areas like palms and soles. Mutations in the KRT9 gene are linked to autosomal dominant epidermolytic palmoplantar keratoderma (EPPK), a skin disorder marked by hyperkeratosis. The KRT9 antibody is widely used in research and diagnostics to detect KRT9 protein expression, assess tissue-specific differentiation, and investigate pathogenic mechanisms in keratinization disorders. It is commonly employed in immunohistochemistry (IHC), Western blotting, and immunofluorescence to visualize KRT9 distribution in epidermal layers. Commercially available as monoclonal or polyclonal variants, this antibody aids in distinguishing EPPK from other keratodermas with overlapping clinical features. Its specificity also supports studies on epithelial cell biology, wound healing, and tumor profiling, as altered keratin expression is observed in certain carcinomas. Validation of KRT9 antibodies emphasizes reactivity to the 62 kDa protein and absence of cross-reactivity with other keratins, ensuring accuracy in both experimental and clinical contexts.