Mouse Monoclonal PAX8 Antibody

The PAX8 antibody is a valuable tool in diagnostic pathology, primarily used to identify tissues and tumors originating from the thyroid, kidney, and Müllerian duct-derived organs (e.g., ovaries, fallopian tubes). PAX8. a member of the PAX (paired box) transcription factor family, plays a critical role in embryonic development and cellular differentiation of these organs. It regulates gene expression by binding to DNA through its conserved paired box domain, ensuring proper organogenesis and tissue-specific functions. In clinical practice, PAX8 immunohistochemistry (IHC) helps distinguish primary tumors from metastatic lesions. For instance, thyroid carcinomas (e.g., papillary, follicular) and renal cell carcinomas typically show strong PAX8 nuclear staining, while Müllerian tumors (e.g., ovarian serous carcinomas) also exhibit positivity. Its specificity makes it particularly useful in differentiating gynecological cancers from gastrointestinal or breast malignancies, which often lack PAX8 expression. Additionally, PAX8 is expressed in benign tissues, aiding in confirming tissue origin in complex cases. However, interpretation requires caution, as PAX8 can occasionally be detected in non-target malignancies (e.g., neuroendocrine tumors). Despite this, its role in confirming organ lineage and resolving diagnostic uncertainties has solidified PAX8 antibody as a cornerstone in tumor classification and precision oncology.