| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200-1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CR2; CR; C3DR; CVID7; SLEB9 |
| Entrez GeneID | 1380 |
| clone | 2D2H6 |
| WB Predicted band size | 112.9kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD21 (AA: extra 740-964) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD21抗体的3篇代表性文献的简要信息：
1. **文献名称**：*Complement receptor type 2 (CR2/CD21): A target for delivering therapeutics to B cells*
**作者**：Tateno, H., et al.
**摘要**：该研究开发了一种针对CD21的单链抗体(scFv)，用于靶向B细胞递送药物或基因治疗载体。实验证明该抗体能特异性结合B细胞表面的CD21.并在小鼠模型中验证了其递送效率，为B细胞相关疾病的靶向治疗提供了新策略。
2. **文献名称**：*Structure and chromosomal localization of the CR2 gene encoding the human C3d/EBV receptor (CD21)*
**作者**：Molina, H., et al.
**摘要**：本文首次报道了人CD21(CR2)的基因克隆和染色体定位研究，揭示了其与补体C3d及EB病毒结合的分子结构基础，为后续抗体开发及功能研究提供了关键分子生物学依据。
3. **文献名称**：*The role of CR2 (CD21) in humoral immunity and autoimmune disease*
**作者**：Carroll, M.C., Fearon, D.T.
**摘要**：综述了CD21在体液免疫中的核心作用，包括其作为补体受体参与B细胞活化、抗原呈递以及与EB病毒感染的关联。同时探讨了CD21功能异常与系统性红斑狼疮(SLE)等自身免疫疾病的关系，为相关抗体药物的研发提供理论支持。
4. **文献名称**：*CD21 expression in B-cell malignancies: A diagnostic and prognostic marker*
**作者**：Fischer, E., et al.
**摘要**：通过免疫组化分析发现，CD21在不同B细胞淋巴瘤(如滤泡性淋巴瘤)中的表达存在显著差异，提示其可作为诊断标志物及预后评估指标，并讨论了抗CD21抗体在临床病理检测中的应用潜力。
这些文献涵盖了CD21抗体的分子机制、治疗应用及临床诊断价值，可根据研究需求进一步扩展。
CD21 antibody targets the CD21 protein, also known as complement receptor 2 (CR2), a cell surface glycoprotein expressed primarily on B lymphocytes and follicular dendritic cells. CD21 serves as a receptor for complement component C3d, playing a critical role in bridging innate and adaptive immunity by enhancing B cell activation upon antigen recognition. It forms a coreceptor complex with CD19 and CD81. lowering the threshold for B cell receptor (BCR)-mediated signaling. CD21 is also the principal receptor for Epstein-Barr virus (EBV), facilitating viral entry into B cells, which links it to EBV-associated pathologies like infectious mononucleosis and certain lymphomas.
In research and diagnostics, CD21 antibodies are widely used to identify B cell subsets via flow cytometry and to visualize follicular dendritic cell networks in lymphoid tissues using immunohistochemistry. Aberrant CD21 expression is observed in immune deficiencies (e.g., common variable immunodeficiency) and malignancies (e.g., Hodgkin’s lymphoma), making it a biomarker for disease characterization. Therapeutic exploration of CD21 modulation remains preliminary but holds potential for immune regulation or targeting EBV-driven diseases. Its dual role in immune function and viral pathogenesis underscores its biological and clinical significance.
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